Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution
Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution
复制标题
DOI：
10.1097/00007632-200107150-00010
复制
发表时间：
2001-07-15
期刊：
影响因子：
3
通讯作者：
Huiskes, R
中科院分区：
文献类型：
--
作者：
Homminga, J;Weinans, H;Huiskes, R
研究设计.一项有限元研究，旨在调查健康、骨质疏松和骨质疏松的脊椎骨中有骨折风险的骨小梁数量以及骨小梁核心和皮质壳之间的载荷分布。确定健康、骨质疏松和骨质疏松椎体在骨折风险和载荷分布方面的差异。文献中没有关于骨质减少和骨质疏松对椎体载荷分布影响的报道，也没有关于骨小梁数量的报道。椎体的计算机断层扫描数据用于构建患者特定的有限元模型。然后将这些模型用于有限元分析，以确定脊椎中的生理应力和应变。对于所有三类椎骨，骨小梁核心对总载荷传递的贡献从终板附近的约70%下降到中横突区域的约50%。对于健康的椎骨，有骨折风险的松质骨的量约为1%，骨质疏松的椎骨约为3%，骨质疏松的椎骨约为16%。我们的有限元模型表明，无论是骨质疏松症或骨质疏松症的贡献，骨小梁核心的总负荷放在椎骨上没有任何影响。骨小梁核心承担了大约一半的负荷。我们的有限元模型表明，骨质疏松症对骨折风险的骨小梁数量有显著影响，从健康椎骨的约1%增加到骨质疏松椎骨的约16%。
Study Design. A finite-element study to investigate the amount of trabecular bone at risk of fracture and the distribution of load between trabecular core and cortical shell, for healthy, osteopenic, and osteoporotic vertebrae.Objectives. To determine differences between healthy, osteopenic, and osteoporotic vertebrae with regard to the risk of fracture and the load distribution.Summary of Background Data. The literature contains no reports on the effects of osteopenia and osteoporosis on load distribution in vertebral bodies, nor any reports on the amount of trabecular bone at risk of fracture.Methods. Computed tomography data of vertebral bodies were used to construct patient-specific finite-element models. These models were then used in finite-element analyses to determine the physiologic stresses and strains in the vertebrae.Results. For all three classes of vertebrae the contribution of the trabecular core to the total load transfer decreased from about 70% near the endplates to about 50% in the midtransverse region. The amount of trabecular bone that is at risk of fracture was about 1% for healthy vertebrae, about 3% for osteopenic vertebrae, and about 16% for osteoporotic vertebrae.Conclusions. Our finite-element models indicated that neither osteopenia nor osteoporosis had any effect on the contribution of the trabecular core to the total load placed on the vertebra. The trabecular core carried about half the load. Our finite-element models indicated that osteoporosis had a significant effect on the amount of trabecular bone at risk of fracture, which increased from about 1% in healthy vertebrae to about 16% for osteoporotic vertebrae.