Presence of nicotinic acetylcholine receptors in cat carotid body afferent system.
Presence of nicotinic acetylcholine receptors in cat carotid body afferent system.
复制标题
猫颈动脉体传入系统中存在烟碱乙酰胆碱受体。
DOI：
10.1016/s0006-8993(98)01015-4
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发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Fitzgerald,RS
中科院分区：
文献类型：
--
作者：
Shirahata,M;Ishizawa,Y;Rudisill,M;Schofield,B;Fitzgerald,RS
利用神经元烟碱乙酰胆碱受体α7亚基单克隆抗体的免疫细胞化学技术，我们发现这些亚基仅在颈动脉体的神经纤维中表达。免疫双染显示α7亚单位阳性神经末梢包裹酪氨酸羟化酶阳性的血管球细胞。部分颈动脉窦神经纤维和酪氨酸羟化酶阳性岩神经节神经元也表达α7亚单位。这些数据支持乙酰胆碱在颈动脉体神经传递中的作用。
With immunocytochemical techniques using a monoclonal antibody for α7 subunits of neuronal nicotinic acetylcholine receptors, we have found these subunits to be exclusively expressed in nerve fibers in the carotid body. Double-immunostaining showed that α7 subunit-positive nerve endings enveloped tyrosine hydroxylase-positive glomus cells. Some carotid sinus nerve fibers and tyrosine hydroxylase-positive petrosal ganglion neurons also expressed α7 subunits. These data support a role for acetylcholine in carotid body neurotransmission.