TREATMENT OF LYME BORRELIOSIS - RANDOMIZED COMPARISON OF DOXYCYCLINE AND PENICILLIN-G
TREATMENT OF LYME BORRELIOSIS - RANDOMIZED COMPARISON OF DOXYCYCLINE AND PENICILLIN-G
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DOI：
10.1007/bf00328508
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发表时间：
1989-01-01
影响因子：
6
通讯作者：
MERTENS, HG
中科院分区：
文献类型：
--
作者：
KOHLHEPP, W;OSCHMANN, P;MERTENS, HG
75例有莱姆病神经症状的患者被随机分配到青霉素G或强力霉素静脉治疗组。12个月后，治疗在临床表现和实验室检查结果方面同样有效。没有患者被认为是治疗失败。然而，三分之一的患者表现出延迟恢复，特别是在较长的原发性疾病持续时间之后。亚急性或慢性疏螺旋体病的典型症状是恢复缓慢，持续数年。
Seventy-five patients with neurological symptoms of Lyme borreliosis were randomly assigned to intravenous treatment with either penicillin G or doxycycyline. After 12 months the treatments were equally effective regarding the clinical picture and laboratory findings. No patient was considered to be a treatment failure. However, one-third of the patients showed delayed recovery, particularly after a longer primary disease duration. A slow recovery, lasting years, was typical of subacute or chronic borreliosis.