The association between low bone mass at the menopause and cardiovascular mortality
The association between low bone mass at the menopause and cardiovascular mortality
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DOI：
10.1016/s0002-9343(99)00028-5
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发表时间：
1999-03-01
影响因子：
5.9
通讯作者：
Hassager, C
中科院分区：
文献类型：
--
作者：
von der Recke, P;Hansen, MA;Hassager, C
背景：绝经后期妇女的低骨密度与非创伤性死亡率增加有关。我们调查了绝经后妇女的骨量是否也与以后生活中的死亡风险有关。方法：在1977年和1988年之间，两个健康妇女样本被纳入;一组在绝经后不久（年龄50 +/- 2岁[平均值+/- SD]，n = 309），另一组在绝经后较晚（年龄70 +/- 2岁，n = 754）。基线访视包括医学检查和前臂远端骨矿物质含量的测量。1994年，检查了生命状况。登记了所有死亡原因，但不包括创伤或自杀造成的死亡。结果：在绝经早期组中，骨矿含量每降低一个标准差（0.4g/cm），死亡率增加43%（RR = 1.4; 95%CI 1.0 ~ 2.0; P
BACKGROUND: Low bone mineral density in late postmenopausal women has been associated with increased nontrauma mortality. We investigated whether bone mass in women soon after menopause was also associated with the risk of mortality in later life.METHODS: Between 1977 and 1988, two samples of healthy women were enrolled; one group soon after the menopause (age 50 +/- 2 years [mean +/- SD], n = 309) and another later after menopause (age 70 +/- 2 years, n = 754). The baseline visit in eluded a medical examination and a measurement of bone mineral content in the distal forearm. In 1994, vital status was checked. All causes of death were registered, excluding those that were due to trauma or suicide. Multivariate relative risks (RR) and 95% confidence intervals (CI)were determined.RESULTS: In the early postmenopausal group, each decrease of one SD (0.4 g/cm) in bone mineral content was associated with a 43% increase in mortality (RR = 1.4; 95% CI 1.0 to 2.0; P