Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb
Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb
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DOI：
10.1159/000059344
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发表时间：
2001-01-01
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影响因子：
--
通讯作者：
Bullerdiek, J
中科院分区：
文献类型：
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作者：
Bol, S;Belge, G;Bullerdiek, J
涉及染色体2p21带的结构重排表征良性甲状腺肿瘤的细胞遗传学亚群。为了缩小这些畸变的断点，我们建立了两个良性甲状腺肿瘤细胞系，显示涉及2p21的易位。将这两种细胞系和一种额外的原发性肿瘤用于18个BAC克隆的FISH研究。所有断裂点被定位到约450kb的簇。版权所有（C）2002 S. Karger AG，巴塞尔。
Structural rearrangements involving chromosome band 2p21 characterize a cytogenetic subgroup of benign thyroid tumors. To narrow down the breakpoints of these aberrations, we established two cell lines from benign thyroid tumors showing translocations involving 2p21. These two cell lines and one additional primary tumor were used for FISH-studies with 18 BAC clones. All breakpoints were mapped to a cluster of about 450 kb. Copyright (C) 2002 S. Karger AG, Basel.