The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema
The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema
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DOI：
10.1007/s00417-020-04759-9
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发表时间：
2020-05-26
影响因子：
2.7
通讯作者：
Obata, Ryo
中科院分区：
文献类型：
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作者：
Fujino, Ryosuke;Asaoka, Ryo;Obata, Ryo
目的评价抗血管内皮生长因子（anti-VEGF）治疗视网膜分支静脉阻塞（BVO）合并黄斑水肿（ME）后视网膜敏感性的价值。方法对20例BVO合并ME患者在基线和抗vegf治疗后1个月进行最佳矫正视力（BCVA）、显微视力和光学相干断层扫描（OCT）测量。探讨BCVA与平均视网膜灵敏度（MS）、黄斑体积（MV）、视网膜中央厚度（CRT）、椭球区完整性（EZ）、最受影响象限平均视网膜灵敏度（qMS）、最受影响象限黄斑体积（qMV）之间的关系。分析1个月时BCVA的变化（Delta BCVA1m）、1个月时最受影响象限的平均敏感性（Delta qMS1m）、1个月时最受影响象限的MV （Delta qMV1m）、1个月时CRT （Delta CRT1m）之间的关系。确定治疗后3个月BCVA的最佳模型（BCVA3m）。结果治疗前后两组患者BCVA差异无统计学意义（配对Wilcoxon检验，p = 0.058）， MS、MV、CRT、qMS、qMV差异有统计学意义（p < 0.05）。Delta qMS1m分别与Delta MV1m、Delta CRT1m、Delta qMV1m存在显著相关。在BCVA3m的最优模型中，选择Delta MS1m或Delta qMS1m、基线时的BCVA和Delta BCVA1m作为解释变量。结论视网膜敏感性与视网膜结构有关，而BCVA与视网膜结构无关。此外，视网膜敏感性可用于预测抗vegf治疗后的BCVA。
Purpose To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (Delta BCVA1m), mean sensitivity in the most affected quadrant at 1 month (Delta qMS1m), MV in the most affected quadrant at 1 month (Delta qMV1m), and CRT at 1 month (Delta CRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified. Results There was not a significant difference in BCVA (paired Wilcoxon test,p = 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (p < 0.05). There was a significant relationship between Delta qMS1m and Delta MV1m, Delta CRT1m, and Delta qMV1m, respectively. Delta MS1m or Delta qMS1m and BCVA at baseline and Delta BCVA1m were selected as explanatory variables in the optimal model for BCVA3m. Conclusion Retinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.