Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells: inhibition by ganglioside GT but not retinoic acid.
Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells: inhibition by ganglioside GT but not retinoic acid.
复制标题
过氧化苯甲酰促进 JB6 小鼠表皮细胞转化：受神经节苷脂 GT 抑制，但不受视黄酸抑制。
DOI：
10.1093/carcin/6.2.309
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发表时间：
1985
期刊：
影响因子：
4.7
通讯作者：
N. Colburn
中科院分区：
文献类型：
--
作者：
T. Gindhart;L. Srinivas;N. Colburn
过氧苯甲酰（BzPo）是一种对小鼠皮肤具有促肿瘤活性的自由基发生剂，在体外可促进JB6小鼠表皮细胞的肿瘤转化。需要反复暴露于BzPo以容易地检测JB6细胞转化的促进。BzPo治疗与该系统中的其他肿瘤促进剂一样，主要表皮神经节苷脂三唾液酸神经节苷脂GT 1b（GT）的净合成显著减少。添加神经节苷脂GT可防止BzPo转化，而视黄酸则不能。
Benzoyl peroxide (BzPo), a free radical generator with tumor promoting activity on mouse skin, is shown to promote neoplastic transformation of JB6 mouse epidermal cells in vitro. Repeated exposures to BzPo are required to readily detect promotion of transformation of JB6 cells. Markedly reduced net synthesis of the major epidermal ganglioside, trisialoganglioside GT1b, (GT) occurs with BzPo treatment as with other tumor promoters active in this system. Addition of ganglioside GT prevents transformation by BzPo while retinoic acid does not.