The lupus anticoagulant in 14 male patients.
The lupus anticoagulant in 14 male patients.
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14 名男性患者的狼疮抗凝剂。
DOI：
10.1001/jama.1982.03330190057033
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
J. A. Brown
中科院分区：
文献类型：
--
作者：
C. C. Waddell;J. A. Brown
14名接受部分凝血活酶时间延长检查的男性患者被发现患有狼疮抗凝剂。与以前的报告相比，梅毒血清学测试的假阳性发生率没有增加。只有两名患者被确诊为系统性红斑狼疮，尽管另外两名患者的抗核抗体检测结果呈阳性。其他临床诊断包括外周血管疾病、心脏病、肺部疾病和精神分裂症。只有两名患者的凝血酶原时间明显异常。出血在这些患者中很少发生，包括10名接受了手术或某种止血挑战的患者。血小板减少与出血无关，但在两名发生血栓事件的患者中出现。
Fourteen male patients examined for a prolonged partial thromboplastin time were found to have the lupus anticoagulant. In contrast to previous reports, there was no increased incidence of false-positive results of serological tests for syphilis. In only two patients was systemic lupus erythematosus confirmed, although two additional patients had a positive result of a test for antinuclear antibody. Other clinical diagnoses included peripheral vascular disease, cardiac disease, pulmonary disease, and schizophrenia. Prothrombin times were distinctly abnormal in only two patients. Bleeding was rarely encountered in these patients, including ten who underwent surgical procedures or some type of hemostatic challenge. Thrombocytopenia was not associated with bleeding but was present in two patients who had thrombotic events.