MRI-clinical correlations in the primary progressive course of MS: new insights into the disease pathophysiology from the application of magnetization transfer, diffusion tensor, and functional MRI
MRI-clinical correlations in the primary progressive course of MS: new insights into the disease pathophysiology from the application of magnetization transfer, diffusion tensor, and functional MRI
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DOI：
10.1016/s0022-510x(02)00131-4
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发表时间：
2003-02-15
影响因子：
4.4
通讯作者：
Filippi, M
中科院分区：
文献类型：
--
作者：
Filippi, M
尽管原发性进行性多发性硬化症 (PPMS) 患者从发病起就经历了进行性病程，但传统脑部磁共振成像 (MRI) 扫描中病变的负担和活动性低于 MS 的所有其他主要临床表型。本综述概述了磁化转移 MRI、扩散张量 MRI 和功能 MRI 对理解 PPMS 病理生理学的主要贡献，并提供了证据，证明至少三个因素可以解释这种临床/MRI 差异：(a) 微观水平上存在弥漫性组织损伤； (b) 颈髓普遍受累，以及 (c) 皮质适应能力受损，限制皮质下结构损伤的功能后果。 (C) 2002 Elsevier Science B.V. 保留所有权利。
Despite patients with primary progressive multiple sclerosis (PPMS) experience a progressive disease course from onset, the burden and activity of lesions on conventional magnetic resonance imaging (MRI) scans of the brain are lower than in all other main clinical phenotypes of MS. This review outlines the major contributions given by magnetization transfer MRI, diffusion tensor MRI and functional MRI to the understanding of the pathophysiology of PPMS and provides evidence that, at least, three factors might explain this clinical/MRI discrepancy: (a) the presence of a diffuse tissue damage at a microscopic level; (b) a prevalent involvement of the cervical cord, and (c) an impairment of the adaptive capacity of the cortex to limit the functional consequences of subcortical structural damage. (C) 2002 Elsevier Science B.V. All rights reserved.