Mechanically Robust, Softening Shape Memory Polymer Probes for Intracortical Recording
Mechanically Robust, Softening Shape Memory Polymer Probes for Intracortical Recording
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DOI：
10.3390/mi11060619
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发表时间：
2020-06-01
期刊：
影响因子：
3.4
通讯作者：
Pancrazio, Joseph J.
中科院分区：
文献类型：
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作者：
Stiller, Allison M.;Usoro, Joshua O.;Pancrazio, Joseph J.
虽然皮质内微电极阵列（MEAs）可能在各种基础和临床场景中有用，但它们的实施受到各种因素的阻碍，其中许多因素与设备的刚性材料组成有关。mea通常由高模量材料（如硅）制造，使得器件容易发生脆性断裂，从而使器件制造和处理复杂化。因此，基于聚合物的器件正在被大量研究；然而，由于机械不稳定，在植入过程中需要插入辅助设备，它们的实施通常很困难。在这项研究中，我们设计并制造了一种形状记忆聚合物（SMP）衬底的皮质内mea，该衬底在室温下保持硬度，但在植入后会软化至20mpa，因此可以在没有辅助的情况下植入设备。我们展示了大鼠皮层16周的慢性记录和电化学测量，并表明该设备对物理变形具有稳定期，因此有利于手术实施。
While intracortical microelectrode arrays (MEAs) may be useful in a variety of basic and clinical scenarios, their implementation is hindered by a variety of factors, many of which are related to the stiff material composition of the device. MEAs are often fabricated from high modulus materials such as silicon, leaving devices vulnerable to brittle fracture and thus complicating device fabrication and handling. For this reason, polymer-based devices are being heavily investigated; however, their implementation is often difficult due to mechanical instability that requires insertion aids during implantation. In this study, we design and fabricate intracortical MEAs from a shape memory polymer (SMP) substrate that remains stiff at room temperature but softens to 20 MPa after implantation, therefore allowing the device to be implanted without aids. We demonstrate chronic recordings and electrochemical measurements for 16 weeks in rat cortex and show that the devices are robust to physical deformation, therefore making them advantageous for surgical implementation.