Use of 2,2'-dithiobis(5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group
Use of 2,2'-dithiobis(5-nitropyridine) for the heterodimerization of cysteine containing peptides. Introduction of the 5-nitro-2-pyridinesulfenyl group
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DOI：
10.1016/0040-4039(96)00019-6
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发表时间：
1996-02-26
影响因子：
1.8
通讯作者：
Dutton, PL
中科院分区：
文献类型：
--
作者：
Rabanal, F;DeGrado, WF;Dutton, PL
2，2 '-二硫代双（5-硝基吡啶）已被证明是用于活化肽中半胱氨酸的巯基功能和随后的不对称二硫键形成的合适试剂。在从头设计的细胞色素模型异源二聚体62-mer肽的制备中测试该试剂的效用。
2,2'-Dithiobis(5-nitropyridine) has proven to be a suitable reagent for the activation of the thiol function of cysteine in peptides and subsequent asymmetric disulfide formation. The utility of this reagent is tested in the preparation of de novo designed cytochrome model heterodimeric 62-mer peptides.