Plasma 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol concentrations are decreased in hind limb unloaded Dahl salt-sensitive female rats.
Plasma 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol concentrations are decreased in hind limb unloaded Dahl salt-sensitive female rats.
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后肢无负载的 Dahl 盐敏感雌性大鼠血浆 25-羟基胆钙化醇和 1,25-二羟基胆钙化醇浓度降低。
DOI：
10.1016/j.jsbmb.2009.12.012
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Cephas,Stacy
中科院分区：
文献类型：
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作者：
Thierry-Palmer,Myrtle;Cephas,Stacy
在几项研究中，当基线血浆25-羟基维生素D（25-OHD）浓度低于最佳水平时，血浆1，25-二羟基维生素D（1，25-（OH）2D）浓度在卧床休息期间降低。Dahl盐敏感性雌性（S）大鼠（而非Dahl盐耐受性雌性（R）大鼠）在低盐摄入（0.3%）期间后肢卸载（HU，废用模型）28天后，血浆1，25-二羟基胆钙化醇（1，25-（OH）2D 3）浓度降低50%。我们测试了雌性S大鼠在高盐摄入期间对后肢卸载的维生素D内分泌系统反应（2%，是标准大鼠食物的两倍，以模拟美国的盐摄入量）。后肢去负荷后，S-HU组大鼠血浆25-OHD 3浓度显著低于R-HU组（P<0.05），S-HU组大鼠25-OHD 3的尿丢失量显著高于S组（P<0.05）。S-HU大鼠血浆1，25-（OH）_2D_3浓度为S大鼠的一半，而R-HU大鼠则无变化。低血浆25-OHD浓度与后肢卸载大鼠和卧床休息参与者血浆1，25-（OH）2D浓度降低的相关性（已发表的研究）表明，低维生素D状态可能是长期固定或卧床休息期间血浆维生素D激素浓度降低的风险因素。
Plasma 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentration was shown to decrease during bed rest in several studies when baseline plasma 25-hydroxyvitamin D (25-OHD) concentration was sub-optimal. Dahl salt-sensitive female (S) rats, but not Dahl salt-resistant female (R) rats, demonstrated a 50% decrease in plasma 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) concentration after 28 days of hind limb unloading (HU, disuse model) during low salt intake (0.3%). We tested the vitamin D endocrine system response of female S rats to hind limb unloading during high salt intake (2%, twice that of standard rat chow to mimic salt intake in the USA). Hind limb unloading resulted in lower plasma 25-OHD3concentrations in S-HU rats than in R-HU rats (P<0.05) and greater urinary loss of 25-OHD3by S-HU rats than by S rats (P<0.05). Plasma 1,25-(OH)2D3concentration of S-HU rats was half that of S rats, but was unchanged in R-HU rats. The association of low plasma 25-OHD concentration with decrease in plasma 1,25-(OH)2D concentration of hind limb unloaded rats and of bed rest participants (published studies) suggests that low vitamin D status might be a risk factor for decrease in plasma vitamin D hormone concentration during long-term immobilization or bed rest.