CAUDATE-NUCLEUS AND MEMORY FOR EGOCENTRIC LOCALIZATION
CAUDATE-NUCLEUS AND MEMORY FOR EGOCENTRIC LOCALIZATION
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DOI：
10.1016/s0163-1047(88)90338-x
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发表时间：
1988-05-01
期刊：
影响因子：
--
通讯作者：
KESNER, RP
中科院分区：
文献类型：
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作者：
COOK, D;KESNER, RP
大量证据表明尾状核在空间定位信息的加工中起着关键作用。此外，越来越多的证据表明，CN参与了一类非常特殊的空间线索的处理，即自我中心线索（相对于生物体的定位）。这与异中心定位（allocentric localization）相反，异中心定位是指生物体根据外部线索进行定位。因此，我们可以预测，CN的损伤应该会破坏主要依赖于自我中心空间线索的任何任务的表现，而不会影响非自我中心任务的表现。为了验证这一预测，两组大鼠接受了两种不同的自我中心记忆任务和两种不同的非自我中心记忆任务的训练。具体来说，一组大鼠训练的相邻臂（自我中心）和8臂径向迷宫任务（allocentric）。第二组大鼠接受左右辨别（自我中心）和位置学习任务（非自我中心）的训练。训练后，两组均接受双侧CN病变。结果表明，CN损伤的动物深刻受损的保留自我中心的任务。与此形成鲜明对比的是，相同的动物没有或只是短暂受损或短暂影响allocentric任务。假手术对照组在所有任务上均未受损或短暂受影响。这些发现进一步支持了这样的想法，即CN在处理自我中心的空间线索，而不是allocentric空间线索中起着重要的调节作用。
A large body of evidence suggests that the caudate nucleus (CN) plays a critical role in the processing of spatial localization information. Furthermore, evidence has begun to accumulate that the CN is involved in the processing of a very specific class of spatial cues, namely egocentric cues (localization with reference to the organism). This is in contrast to allocentric localization, where an organism localizes on the basis of cues external to the organism. One would then predict that lesions to the CN should disrupt performance on any tasks that depend chiefly on egocentric spatial cues, while leaving performance on allocentric tasks intact. To test this prediction, two groups of rats were trained on two different egocentric memory tasks and two different allocentric memory tasks. Specifically, one group of rats was trained on an adjacent-arm (egocentric) and an 8-arm radial maze task (allocentric). A second group of rats was trained on a right-left discrimination (egocentric) and a place-learning task (allocentric). After training, both groups received bilateral lesions of the CN. Results showed that CN-lesioned animals were profoundly impaired on retention of the egocentric tasks. In sharp contrast to this, the same animals were not or were only transiently impaired or transiently affected on allocentric tasks. Sham-operated controls were either unimpaired or transiently affected on all tasks. These findings further support the idea that the CN plays a critical modulatory role in the processing of egocentric spatial and not allocentric spatial cues.