Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP?
Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP?
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DOI：
10.1126/stke.2312004pe19
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发表时间：
2004-04-28
期刊：
影响因子：
--
通讯作者：
Insel, Paul A
中科院分区：
文献类型：
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作者：
Bundey, Richard A;Insel, Paul A
可溶性腺苷酸环化酶可以在细胞核中发挥作用，限定腺苷3 '，5'-单磷酸（cAMP）信号传导的细胞核微区。Bundey和Insel讨论了cAMP的离散信号微区的证据，包括细胞核和小窝，并得出结论，这些微区可能是由腺苷酸环化酶亚型的局部亚细胞表达定义的。
Soluble adenylyl cyclase can function in the nucleus, defining a nuclear microdomain of adenosine 3',5'-monophosphate (cAMP) signaling. Bundey and Insel discuss the evidence for discrete signaling microdomains of cAMP, including the nucleus and caveolae, and conclude that such microdomains may be defined by the localized, subcellular expression of adenylyl cyclase isoforms.