COMMON MODE OF ACTION OF 3 AGENTS THAT DECREASE TRANSIENT CHANGE IN SODIUM PERMEABILITY IN NERVES

COMMON MODE OF ACTION OF 3 AGENTS THAT DECREASE TRANSIENT CHANGE IN SODIUM PERMEABILITY IN NERVES
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DOI:
10.1038/2101220a0
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发表时间:
1966-01-01
期刊:
影响因子:
64.8
通讯作者:
HILLE, B
HILLE, B
中科院分区:
综合性期刊1区
文献类型:
--
作者:
HILLE, B

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本文报道了一种强效毒素、一种局部麻醉剂和一种镇静剂[对尖音蛙淋巴结]的快速、可逆作用的电压钳分析。所有3个都影响Hodgkin-Huxley模型中的钠电导。这种变化可以用物理模型来解释。
This article reports voltage-clamp analyses of the rapid, reversible effects of a powerful toxin, a local anesthetic, and a tranquillizer [on Rana pipiens nodes]. All 3 affect the sodium conductance in the Hodgkin-Huxley model. This change can be interpreted in terms of a physical model.