Multifactorial causation of obesity: implications for prevention
Multifactorial causation of obesity: implications for prevention
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DOI：
10.1093/ajcn/67.3.563s
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发表时间：
1998-03-01
影响因子：
7.1
通讯作者：
Grundy, SM
中科院分区：
文献类型：
--
作者：
Grundy, SM
肥胖有可能成为世界上慢性病的首要原因。肥胖会导致多种代谢异常，导致心血管疾病、糖尿病和其他慢性疾病。不幸的是，肥胖症的流行率在美国和世界范围内都在增加。患病率上升的原因包括世界人口的城市化、粮食供应的增加和身体活动的减少。虽然重度肥胖在临床上受到了很多关注，但大多数普通公众的肥胖只是中度的。即便如此，中度肥胖也会引起一些代谢异常，这些异常是慢性疾病的前兆。因此，对于整个人群来说，中度肥胖是大多数肥胖相关疾病的原因。中度肥胖症无疑是多因素的起源，后天影响可能超过遗传因素的原因。因此，在制定控制一般人群超重的公共卫生战略时，应更加重视这些后天原因。迫切需要一项重大的公共卫生努力来应对美国和全世界中度肥胖的日益增加的频率。
Obesity threatens to become the foremost cause of chronic disease in the world. Being obese can induce multiple metabolic abnormalities that contribute to cardiovascular disease, diabetes mellitus, and other chronic disorders. Unfortunately, prevalence of obesity is increasing both in the United States and worldwide. Reasons for the rising prevalence include urbanization of the world's population, increased availability of food supplies, and reduction of physical activity. Although severe obesity has received much attention in the clinical setting, most obesity in the general public is only moderate. Even so, moderate obesity can elicit several metabolic abnormalities that are precursors to chronic disease. Therefore, for the population as a whole, moderate obesity is responsible for most obesity-related disorders. Moderate obesity is undoubtedly multifactorial in origin, and acquired influences probably exceed genetic factors in its causation. These acquired causes thus deserve greater attention in the development of a public health strategy for the control of overweight in the general population. A major public health effort is urgently needed to counter the increasing frequency of moderate obesity in the United States and throughout the world.