New Adsorbents for Extracorporeal Removal of β2-Microglobulin
New Adsorbents for Extracorporeal Removal of β2-Microglobulin
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用于体外去除 β2-微球蛋白的新型吸附剂
DOI：
10.1007/978-1-4757-0298-9_105
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
R. Nakazawa
中科院分区：
文献类型：
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作者：
S. Furuyoshi;N. Tani;R. Nakazawa
据报道，在慢性血液透析患者的各种组织和器官中经常发现淀粉样蛋白沉积，这种淀粉样蛋白与β-2-微球蛋白(BMG)1同源。为了防止淀粉样蛋白沉积的进展，人们尝试使用改进的血液透析器直接从循环血中去除BMG。然而，由于透析器对BMG的清除率仍低于BMG的产生率，血清BMG水平不能控制在需要的低水平以达到消退或预防的目的。因此，人们希望开发出更强化去除BMG的装置。
It has been reported that the amyloid deposition is frequently found at various tissues and organs in chronic hemodialysis patients,and this amyloid protein is homologous to β2-microglobulin (BMG)1. To prevent the progression of amyloid deposition, the direct removal of BMG from circulating blood has been tried using improved hemodialyzer. However, as the removal rate of BMG by dialyzer is still below the BMG production rate, serum BMG level can not be controlled as low as required for the regression or prevention. Therefore, it is desired that the device for more intensive BMG removal will be developed.