Lipid class distribution of fatty acids including conjugated linoleic acids in healthy and cancerous parts of human kidneys
Lipid class distribution of fatty acids including conjugated linoleic acids in healthy and cancerous parts of human kidneys
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DOI：
10.1007/s11745-005-1469-y
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发表时间：
2005-10-01
期刊：
影响因子：
1.9
通讯作者：
Steinhart, H
中科院分区：
文献类型：
--
作者：
Hoffmann, K;Blaudszun, J;Steinhart, H
本研究比较了同一患者健康肾组织和癌性肾组织的脂肪酸组成，特别是CLA和PUFA的含量。CLA优先纳入中性脂质相比，磷脂类。其分布概况与单不饱和FA相似，但与1 8：2n-6不同。不同的掺入模式，发现个别CLA异构体。比较肾细胞癌（RCC）和健康肾，总CLA含量显着较低的胆固醇酯馏分和显着较高的PE和PS馏分从RCC。正常肾组织与癌组织中t10、c12-CLA含量差异最显著。此外，n-6多不饱和脂肪酸的脂质类分布进行了测定，并发现RCC和健康肾组织之间存在一些显着差异，这是有趣的，因为它已被提出，饮食共轭亚油酸的抗癌特性与他们的干扰代谢的20：4 n-6。本研究的设计不能明确证明CLA参与预防肾癌，也不打算这样做，但完整测定邻近健康和癌组织的FA组成可能会提供一个见解，如果脂质参与这种疾病。
In this study the FA compositions of healthy and cancerous human renal tissues from the same patients are compared with special reference to the CLA and PUFA content. CLA was preferentially incorporated into neutral lipid compared with phospholipid classes. Its distribution profile was similar to that of monounsaturated FA, but unlike that found with 1 8:2n-6. Different incorporation patterns were found for individual CLA isomers. Comparing renal cell carcinoma (RCC) and healthy kidney, the total CLA content was significantly lower in the cholesterylester fraction and significantly higher in the PE and PS fractions from RCC. The most significant differences between healthy and cancerous renal tissue were in the content of t10,c12-CLA. Furthermore, the lipid class distributions of n-6 PUFA were determined, and several significant differences between RCC and healthy renal tissue were found. This is of interest, as it has been proposed that the anticarcinogenic properties of dietary CLA are associated with their interference in the metabolism of 20:4n-6. The involvement of CLA in preventing renal cancer cannot be definitively demonstrated from the design of this study, nor was it intended, but the complete determination of the FA composition of adjacent healthy and cancerous tissues may provide an insight if lipids are involved in this disease.