CONGENITAL LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IN TWINS
CONGENITAL LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION IN TWINS
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DOI：
10.1097/00006454-199311000-00010
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发表时间：
1993-11-01
影响因子：
3.6
通讯作者：
YOSHINO, MT
中科院分区：
文献类型：
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作者：
BARTON, LL;BUDD, SC;YOSHINO, MT
淋巴细胞性脉络丛脑膜炎病毒（LCMV）是一种由小鼠慢性感染而持续存在的沙粒病毒，在欧洲和美洲一直是散发性和流行性疾病的病原体。“人类感染可能不明显，或与不同严重程度的全身或中枢神经系统（CNS）表现有关。胎儿感染导致宫内或早期新生儿死亡，以及活产婴儿脑积水和脉络膜视网膜炎。“因此，经胎盘LCMV感染是一种潜在的可预防的失明和精神发育迟滞的原因。此前在美国仅报道过一次。病例报告一个9个月大的女孩（双胞胎A）被称为儿科感染性疾病诊所于1992年7月2日，因为小头畸形，视力下降和发育迟缓。她是一个34岁的性病研究的非反应性，风疹免疫性初潮妇女的37周双胞胎妊娠的产物。怀孕13周时，母亲生病使怀孕复杂化，主要表现为恶心、呕吐、发烧、寒战、出汗和肌痛。诊断为咽炎和尿路感染，但咽喉培养结果为A组β-溶血性链球菌阴性，尿培养结果为无菌。患者最初接受静脉注射氨苄青霉素治疗，随后接受口服阿莫西林治疗，共7天。怀孕也是一种-
Lymphocytic choriomeningitis virus (LCMV), an arenavirus perpetuated by chronic infection of mice, has been the agent of sporadic and epidemic disease in Europe and the Americas." Human infection may be inapparent or associated with systemic or central nervous system (CNS) manifestations of varying severity. Fetal infection has resulted in intrauterine or early neonatal death, as well as hydrocephalus and chorioretinitis in liveborn infants." Transplacental LCMV infection is thus a potentially preventable cause of blindness and psychomotor retardation. It has been reported only once previously in the United States." The unique occurrence of congenital LCMV infection in dichorionic twins forms the basis of this report.CASE REPORTS A 9-month-old girl (Twin A) was referred to the pediatric infectious disease clinic on July 2, 1992, because of microcephaly, decreased vision and developmental delay. She was the product of a 37-week twin gestation in a 34-year old Venereal Disease Research Laboratory-nonreactive, rubella-immune primagravida woman. Pregnancy had been complicated by maternal illness at 13 weeks of gestation, notable for nausea, vomiting, fever, chills, sweats and myalgia. The diagnoses of pharyngitis and urinary tract infec-tion were made, but a throat culture was negative for Group A beta-hemolytic streptococci and a urine culture was sterile. She was treated initially with intra-venous ampicillin and subsequently with oral amoxicillin for a total of 7 days. Pregnancy was also re-