Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic
Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic
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DOI：
10.1016/j.clinbiochem.2007.05.021
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发表时间：
2007-11-01
影响因子：
2.8
通讯作者：
Chambers, Stephen T.
中科院分区：
文献类型：
--
作者：
Lever, Michael;Atkinson, Wendy;Chambers, Stephen T.
目的：为了了解男性和女性患者对甜菜碱代谢的控制是否存在差异，并确定胰岛素和其他激素的影响，设计和方法：对来自非糖尿病血脂门诊患者（82名女性和76名男性）的数据按性别进行重新分析。胰岛素，甲状腺激素和瘦素的数据包括在模型中，以确定影响甜菜碱及其代谢产物的循环和排泄的因素。结果：不同的因素影响甜菜碱，二甲基甘氨酸和同型半胱氨酸的血浆浓度和尿排泄的男性和女性。在男性中，载脂蛋白B（阴性）、促甲状腺激素（阳性）和胰岛素（阴性）预测循环甜菜碱，与甜菜碱-高半胱氨酸甲基转移酶介导的对照一致。在雌性动物中，胰岛素阳性预测血浆二甲基甘氨酸。男性尿甜菜碱排泄阳性预测循环同型半胱氨酸（p
Objectives: To find whether the control of betaine metabolism differs between male and female patients and identify the effects of insulin and other hormones.Design and methods: Data from non-diabetic lipid clinic patients (82 female and 76 male) were re-analyied by sex. Data on insulin, thyroid hormones and leptin were included in models to identify factors affecting the circulation and excretion of betaine and its metabolites.Results: Different factors influenced plasma concentrations and urinary excretion of betaine, dimethylglycine and homocysteine in males and females. In males, apolipoprotein B (negative), thyroid stimulating hormone (positive) and insulin (negative) predicted circulating betaine, consistent with betaine-homocysteine methyltransferase mediated control. In females, insulin positively predicted plasma dimethylglycine. Urinary betaine excretion positively predicted circulating homocysteine in males (p