Obesity, Metabolic Syndrome and the Risk of Development of Colonic Diverticulosis
Obesity, Metabolic Syndrome and the Risk of Development of Colonic Diverticulosis
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DOI：
10.1159/000339881
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发表时间：
2012-01-01
期刊：
影响因子：
3.2
通讯作者：
Carter, Dan
中科院分区：
文献类型：
--
作者：
Kopylov, Uri;Ben-Horin, Shomron;Carter, Dan
前言：结肠憩室病是一种常见疾病，发病机制不明。肥胖、高脂血症和高血压可增加复杂性憩室病的风险，但代谢危险因素对非复杂性憩室病患病率的影响尚不清楚。目的：研究肥胖和代谢综合征对结肠憩室病患病率的影响。方法：这项回顾性病例对照研究包括以色列医学筛查研究所在2006-2011年对40-85岁的患者进行了随访，并接受了结肠镜检查，以确定结直肠癌筛查的适应症。将结肠镜检查发现的憩室病患者与非憩室病患者进行比较。比较参数包括病史、生物统计学参数、生化和血脂谱。结果：这项研究包括3175名患者。在队列中，17.4%的人被诊断为憩室病。在单因素分析中，年龄、男性、BMI(连续变量)、肥胖、收缩压、低密度脂蛋白胆固醇水平、高血压病史、缺血性心脏病、甲状腺功能减退和无糖尿病与结肠憩室病的风险增加相关。在多变量分析中，高龄、男性、肥胖(BMI>；30)、甲状腺功能减退史和无糖尿病史与憩室病风险增加相关。在有和没有憩室病的患者中，结肠息肉的患病率相似。结论：结肠憩室病与年龄、男性、肥胖、甲状腺功能减退有关。糖尿病与结肠憩室病的风险降低有关。版权所有(C)2012 S.Karger AG，巴塞尔
Introduction: Colonic diverticulosis is a common condition with obscure pathogenesis. Obesity, hyperlipidemia and hypertension have been demonstrated to increase the risk of complicated diverticular disease, but the impact of metabolic risk factors on the prevalence of uncomplicated diverticulosis has not been clearly determined. Aims: The aim of the study was to examine the impact of obesity and metabolic syndrome on the prevalence of colonic diverticulosis. Methods:This retrospective case-control study included patients aged 40-85 years who were followed up by the Institute of Medical Screening in Israel and underwent colonoscopy in 2006-2011 for indication of colorectal cancer screening. Patients with diverticulosis as detected by colonoscopy were compared to patients without diverticulosis. The comparison parameters included medical history, biometric parameters, biochemical and lipid profile. Results: The study included 3,175 patients. Diverticulosis was diagnosed in 17.4% of the cohort. On univariate analysis, age, male gender, BMI (continuous variable), obesity, systolic blood pressure, low-density lipoprotein cholesterol level, history of hypertension, ischemic heart disease, hypothyroidism, and absence of diabetes mellitus were associated with an increased risk of colonic diverticulosis. On multivariate analysis, advanced age, male gender, obesity (BMI >30), history of hypothyroidism and absence of diabetes mellitus were associated with an increased risk of diverticulosis. Prevalence of colonic polyps was similar in patients with and without diverticulosis. Conclusion: Colonic diverticulosis was associated with age, male gender, obesity and hypothyroidism. Diabetes mellitus was associated with a decreased risk of colonic diverticulosis. Copyright (C) 2012 S. Karger AG, Basel