A single type of progenitor cell maintains normal epidermis
A single type of progenitor cell maintains normal epidermis
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DOI：
10.1038/nature05574
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发表时间：
2007-03-08
期刊：
影响因子：
64.8
通讯作者：
Jones, Philip H.
中科院分区：
文献类型：
--
作者：
Clayton, Elizabeth;Doupe, David P.;Jones, Philip H.
根据成人表皮稳态的当前模型，皮肤组织由两个离散的祖细胞群体维持：自我更新干细胞;和它们的后代，称为转运放大细胞，其在几轮细胞分裂后分化（1-3）。通过利用诱导的遗传标记，我们已经跟踪了小鼠尾表皮祖细胞的代表性样品的命运在体内的时间间隔长达一年的单细胞分辨率。在这里，我们表明，克隆大小分布是一致的一个新的模型，涉及只有一种类型的祖细胞的稳态。发现这些细胞以确保表皮稳态的速率进行对称和不对称分裂。这些结果提出了关于干细胞在体内组织维护中的潜在作用的重要问题。
According to the current model of adult epidermal homeostasis, skin tissue is maintained by two discrete populations of progenitor cells: self-renewing stem cells; and their progeny, known as transit amplifying cells, which differentiate after several rounds of cell division(1-3). By making use of inducible genetic labelling, we have tracked the fate of a representative sample of progenitor cells in mouse tail epidermis at single-cell resolution in vivo at time intervals up to one year. Here we show that clone-size distributions are consistent with a new model of homeostasis involving only one type of progenitor cell. These cells are found to undergo both symmetric and asymmetric division at rates that ensure epidermal homeostasis. The results raise important questions about the potential role of stem cells on tissue maintenance in vivo.