Obesity increases risk of ischemic stroke in young adults.
Obesity increases risk of ischemic stroke in young adults.
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DOI：
10.1161/strokeaha.115.008940
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发表时间：
2015-06
期刊：
影响因子：
8.3
通讯作者：
Kittner SJ
中科院分区：
文献类型：
--
作者：
Mitchell AB;Cole JW;McArdle PF;Cheng YC;Ryan KA;Sparks MJ;Mitchell BD;Kittner SJ
身体质量指数（BMI）与老年人群缺血性中风有关，但其与年轻人群中风的关系尚不清楚。鉴于目前肥胖在美国的流行，肥胖对年轻人中风风险的潜在影响值得关注。采用1201例病例和1154例对照的人群为基础的病例-对照研究设计，探讨肥胖与年轻发病缺血性脑卒中的关系。中风患者的年龄在15岁到49岁之间。采用Logistic回归分析来评估BMI与缺血性卒中之间的关系，并对与卒中相关的合并症进行调整。在对年龄、性别和种族进行校正的分析中，肥胖（体重指数bbb30 kg/m2）与卒中风险增加相关（优势比为1.57,95% ci = 1.28-1.94），尽管在对吸烟、高血压和糖尿病进行校正后，这种增加的风险高度减弱，无统计学意义。这些结果表明，肥胖是年轻发病缺血性中风的一个危险因素，并表明这种关联可能部分通过高血压、糖尿病和/或与这些疾病相关的其他变量介导。
Body mass index (BMI) has been associated with ischemic stroke in older populations, but its association with stroke in younger populations is not known. In light of the current obesity epidemic in the United States, the potential impact of obesity on stroke risk in young adults deserves attention. A population-based case-control study design with 1201 cases and 1154 controls was used to investigate the relationship of obesity and young-onset ischemic stroke. Stroke cases were between the ages of 15 and 49. Logistic regression analysis was used to evaluate the association between BMI and ischemic stroke with and without adjustment for co-morbid conditions associated with stroke. In analyses adjusted for age, sex, and ethnicity, obesity (BMI > 30 kg/m2) was associated with an increased stroke risk (odds ratio, 1.57, 95% C.I. = 1.28–1.94), although this increased risk was highly attenuated and not statistically significant after adjustment for smoking, hypertension, and diabetes mellitus. These results indicate that obesity is a risk factor for young onset ischemic stroke, and suggest that this association may be partially mediated through hypertension, diabetes mellitus, and/or other variables associated with these conditions.