Difference between calculated and direct-measured low-density lipoprotein cholesterol in subjects with diabetes mellitus or taking lipid-lowering medications
Difference between calculated and direct-measured low-density lipoprotein cholesterol in subjects with diabetes mellitus or taking lipid-lowering medications
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DOI：
10.1016/j.jacl.2011.12.007
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发表时间：
2012-04-01
影响因子：
4.4
通讯作者：
Oh, Byung-Hee
中科院分区：
文献类型：
--
作者：
Choi, Su-Yeon;Park, Hyo Eun;Oh, Byung-Hee
目的：我们评估了导致计算出的低密度脂蛋白胆固醇 (C-LDL-C) 与直接测量的 LDL-C (D-LDL-C) 之间存在差异的因素，并在患有糖尿病 (DM) 或服用降脂药物的受试者中进行比较。 方法：21,452 名受试者（9,177 名女性，12,275 名男性；8.1% 患有 DM，8.5% 接受降脂治疗）药物）也包含在分析中。参与者被分为 3 组，即第 1 组：无 DM 且未服用调脂药物的受试者 (n = 18,287)，第 2 组：无 DM 且服用调脂药物的受试者 (n = 1,423)，第 3 组：患有 DM (n = 1,742)。 LDL-C 浓度可通过同质法直接测量或通过 Friedewald 公式计算。结果：C-LDL-C 和 D-LDL-C 之间存在显着相关性 (r = 0.966，P < .001)。两个 LDL-C 值之间差异的绝对值为 7.0 +/- 6.2 mg/dl 和 6.6 +/- 7.3%（6.6 +/- 5.9 mg/dl 和 6.0 +/- 6.5%、8.8 +/- 6.7 mg/dl 和 9.1 +/- 9.7%、以及 10.1 +/- 7.3 mg/dl 和 10.7第 1、2 和 3 组分别为 +/- 10.1%，P < .001)。 LDL-C差异绝对值≥10%的受试者为20.2%（第1组、第2组和第3组分别为17.3%、31.3%和41.1%，P < .001）。在多元Logistic回归分析中，高甘油三酯（>= 150 mg/dl）、低高密度脂蛋白胆固醇（HDL-C）（= 25 kg/m(2)）、糖尿病和服用降脂药物与高LDL差异显着相关（差异的绝对值>= 10%或>= 10 mg/dl）。结论：D-LDL-C普遍高出5倍mg/dl 或比 C-LDL-C 低 5%。糖尿病患者和服用降脂药物的受试者中，C-LDL-C 和 D-LDL-C 的差异较高。男性、高甘油三酯、低 HDL-C 和肥胖也与 C-LDL-C 和 D-LDL-C 之间的较大差异相关。 (C) 2012 年国家脂质协会。版权所有。
OBJECTIVE: We evaluated factors that caused differences between calculated low-density lipoprotein cholesterol (C-LDL-C) and direct-measured LDL-C (D-LDL-C) and compared them in subjects with diabetes mellitus (DM) or taking lipid-lowering medications.METHODS: 21,452 subjects (9,177 women, 12,275 men; 8.1% with DM and 8.5% on lipid-lowering medications) were included in the analysis. Participants were classified into 3 groups, i.e., group 1: the subjects without DM and not on lipid-modifying drugs (n = 18,287), group 2: without DM and on lipid-modifying drugs (n = 1,423), and group 3: with DM (n = 1,742). LDL-C concentrations were either directly measured by a homogenous method or calculated by Friedewald formula.RESULTS: There was a significant correlation between C-LDL-C and D-LDL-C (r = 0.966, P < .001). The absolute values of the differences between two LDL-C values were 7.0 +/- 6.2 mg/dl and 6.6 +/- 7.3% (6.6 +/- 5.9 mg/dl and 6.0 +/- 6.5%, 8.8 +/- 6.7 mg/dl and 9.1 +/- 9.7%, and 10.1 +/- 7.3 mg/dl and 10.7 +/- 10.1% in group 1, 2, and 3 respectively, P < .001). The subjects with the absolute value of the differences of LDL-C >= 10% was 20.2% (17.3%, 31.3%, and 41.1% in group 1, 2, and 3 respectively, P < .001). In the multiple logistic regression analysis, high triglyceride (>= 150 mg/dl), low high-density lipoprotein cholesterol (HDL-C) (= 25 kg/m(2)), DM and taking lipid-lowering drugs were significant associated with high LDL-differences (the absolute value of the differences >= 10% or >= 10 mg/dl).CONCLUSION: D-LDL-C was generally higher by 5 mg/dl or 5% than C-LDL-C. The differences C-LDL-C and D-LDL-C were higher in subjects with DM and on lipid-lowering medications. Male gender, high triglyceride, low HDL-C, and obesity were also associated with the greater differences between C-LDL-C and D-LDL-C. (C) 2012 National Lipid Association. All rights reserved.