A model for restriction fragment length distributions.
A model for restriction fragment length distributions.
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DOI：
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发表时间：
1983-09
影响因子：
9.8
通讯作者：
D. Bishop;J. Williamson;M. Skolnick
中科院分区：
文献类型：
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作者：
D. Bishop;J. Williamson;M. Skolnick
我们在这里开发了一个模型的限制性片段长度分布的基础上，在人类的DNA二聚体的频率。计算已知限制酶的平均片段长度。这个模型是测试使用的数据从杂交的一系列任意单拷贝DNA探针与一组限制性内切酶筛选。与模型的拟合似乎良好。我们将该模型应用于一组酶扫描多少DNA的问题。然后将该结果进一步应用于优化插入/缺失DNA多态性的搜索。
We develop here a model for restriction fragment length distributions based on DNA dimer frequencies in humans. Mean fragment lengths are computed for known restriction enzymes. This model is tested using data from the hybridization of a series of arbitrary single-copy DNA probes screened with a set of restriction enzymes. The fit to the model appears good. We apply the model to the problem of how much DNA is scanned by a set of enzymes. This result is then further applied to optimizing the search for insertion/deletion DNA-polymorphisms.