The effects of heroin administration and drug cues on impulsivity.
The effects of heroin administration and drug cues on impulsivity.
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DOI：
10.1080/13803395.2016.1156652
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发表时间：
2016-08
影响因子：
2.2
通讯作者：
Comer SD
中科院分区：
文献类型：
--
作者：
Jones JD;Vadhan NP;Luba RR;Comer SD
药物成瘾是一种慢性复发性疾病，其特征是强迫性寻求药物并不顾负面后果继续使用。行为冲动性是药物成瘾的开始和维持的一个强有力的预测因素。临床前数据表明，海洛因可能会加剧个人的冲动特征，但这尚未在临床样本中进行评估。目前的二级数据分析试图调查海洛因对冲动的影响沿着暴露于药物线索的影响。使用目前的数据集，我们还初步评估了冲动和海洛因滥用之间的病因学关系。招募16名海洛因依赖者，在重复给予海洛因、急性给予海洛因和药物提示暴露后完成IMT/DMT和GoStop任务。前四天的活性海洛因的可用性，相比前四天的安慰剂药物的可用性，增加冲动使用IMT和DMT评估。药物提示的呈现同样增加了对所有三项任务的冲动性评估。此外，重度吸毒者似乎更容易受到毒品线索对冲动的影响。目前的研究代表了更全面地了解阿片类药物滥用和冲动之间的相互作用的一步。更好地了解这些因素可以为海洛因使用和复吸的维持提供重要见解。
Drug addiction is a chronic relapsing disorder characterized by compulsive drug seeking and continued use despite negative consequences. Behavioral impulsivity is a strong predictor of the initiation and maintenance of drug addiction. Preclinical data suggest that heroin may exacerbate impulsive characteristics in an individual but this has yet to be assessed in clinical samples. The current secondary data analysis sought to investigate the effects of heroin on impulsivity along with the effects of exposure to drug cues. Using the current data set, we also tentatively assessed the etiological relationship between impulsivity and heroin abuse. Sixteen heroin-dependent participants were recruited to complete IMT/DMT and GoStop tasks following repeated heroin administration, acute heroin administration and following a drug cue exposure session. Four preceding days of active heroin availability, compared to four preceding days of placebo drug availability, increased impulsivity assessed using the IMT and DMT. Presentation of drug cues similarly acted to increase impulsivity assessments on all three tasks. It also appears that heavier users were more susceptible to the influence of drug cues on impulsivity. The present study represents a step toward a more comprehensive understanding of the interaction between opioid abuse and impulsivity. A better understanding of these factors could provide critical insight into the maintenance of heroin use and relapse.