Paratyphoid fever: splicing the global analyses.
Paratyphoid fever: splicing the global analyses.
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DOI：
10.7150/ijms.7768
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发表时间：
2014
影响因子：
3.6
通讯作者：
Thong KL
中科院分区：
文献类型：
--
作者：
Teh CS;Chua KH;Thong KL
甲型副伤寒沙门氏菌引起的肠热病的发病率。甲型副伤寒在世界许多地方都在增加。虽然近年来没有发生大规模的副伤寒疫情，但沙门氏菌在我国的流行病学研究中占有重要地位。甲型副伤寒感染仍然是许多热带国家的公共卫生问题。因此，监测研究在监测感染和多重耐药性的出现方面发挥着重要作用，特别是在印度、尼泊尔、巴基斯坦和中国等流行国家。在中国，伤寒主要由沙门氏菌引起。甲型副伤寒而不是伤寒沙门氏菌（S。伤寒）。有时候S甲型副伤寒感染可演变为带菌者，增加传播给旅客的风险。因此，副伤寒通常被归类为“旅行相关”疾病。迄今为止，基于临床表现的副伤寒诊断并不令人满意，因为它类似于其他发热性疾病，并且不能与S。伤寒感染。随着全基因组测序技术的发展，S.甲型副伤寒可以深入研究，并将发现更具体的检测目标。因此，S.与肥达氏试验相比，聚合酶链反应（PCR）法检测甲型副伤寒似乎是一种更可靠的方法。另一方面，由于S.由于甲型副伤寒在世界范围内的感染，生产副伤寒疫苗的必要性和紧迫性。因此，开展了各种涉及临床试验的疫苗项目。总之，这篇评论提供了S。包括甲型副伤寒的细菌学、流行病学、管理和抗生素敏感性、诊断和疫苗开发。
The incidence of enteric fever caused by Salmonella enterica serovar Paratyphi A (S. Paratyphi A) is increasing in many parts of the world. Although there is no major outbreak of paratyphoid fever in recent years, S. Paratyphi A infection still remains a public health problem in many tropical countries. Therefore, surveillance studies play an important role in monitoring infections and the emergence of multidrug resistance, especially in endemic countries such as India, Nepal, Pakistan and China. In China, enteric fever was caused predominantly by S. Paratyphi A rather than by Salmonella enterica serovar Typhi (S. Typhi). Sometimes, S. Paratyphi A infection can evolve into a carrier state which increases the risk of transmission for travellers. Hence, paratyphoid fever is usually classified as a “travel-associated” disease. To date, diagnosis of paratyphoid fever based on the clinical presentation is not satisfactory as it resembles other febrile illnesses, and could not be distinguished from S. Typhi infection. With the availability of Whole Genome Sequencing technology, the genomes of S. Paratyphi A could be studied in-depth and more specific targets for detection will be revealed. Hence, detection of S. Paratyphi A with Polymerase Chain Reaction (PCR) method appears to be a more reliable approach compared to the Widal test. On the other hand, due to increasing incidence of S. Paratyphi A infections worldwide, the need to produce a paratyphoid vaccine is essential and urgent. Hence various vaccine projects that involve clinical trials have been carried out. Overall, this review provides the insights of S. Paratyphi A, including the bacteriology, epidemiology, management and antibiotic susceptibility, diagnoses and vaccine development.
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影响因子：
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作者：
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通讯作者：
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