Prospective study of markers of hemostatic function with risk of ischemic stroke
Prospective study of markers of hemostatic function with risk of ischemic stroke
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DOI：
10.1161/01.cir.100.7.736
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发表时间：
1999-08-17
期刊：
影响因子：
37.8
通讯作者：
Wu, KK
中科院分区：
文献类型：
--
作者：
Folsom, AR;Rosamond, WD;Wu, KK
方法和结果：社区动脉粥样硬化风险研究测量了14700多名年龄在45岁到之间的无心血管疾病的参与者中的几个这些标记物，并对发生缺血性中风的6至9年进行了随访(n=191)，发现缺血性中风的发生率与VIIC因子、抗凝血酶III、血小板计数或激活的部分凝血活酶时间没有明显的相关性。在对多种心血管危险因素进行校正后，在基于连续变量或4/4变量分布的回归分析中，von Willebrand因子、因子VIIIc、纤维蛋白原和白细胞计数呈正相关，蛋白C与缺血性卒中发生率呈负相关，但不显著。调整后的相对危险度(95%CI)为：血管性血友病因子1.71(1.1~2.7)；VIIIc因子1.93(1.2~3.1)；白细胞计数1.50(0.9~2.4)；纤维蛋白原。1.26(0.8到2.0)；和蛋白C，0.65(0.4到1.0)，结论--这项研究为以下假设提供了适度的支持：一些止血功能和炎症的标记物可以识别中风风险增加的中年人群体。这些因素可能在缺血性卒中的发病机制中起一定作用。
Background-Several markers of hemostatic function and inflammation have been associated with increased risk of coronary heart disease, but prospective evidence for their role in ischemic stroke is scant.Methods and Results-The Atherosclerosis Risk in Communities (ARIC) Study measured several of these markers in more than 14 700 participants 45 to 64 years old who were free of cardiovascular disease and were followed up for 6 to 9 years for occurrence of ischemic stroke (n=191), There was no apparent association between ischemic stroke incidence and factor VIIc, antithrombin III. platelet count, or activated partial thromboplastin time. After adjustment for multiple cardiovascular risk factors, von Willebrand factor, factor VIIIc, fibrinogen, and white blood cell count were positively associated and protein C was negatively but nonsignificantly associated with ischemic stroke incidence in regression analyses based on either continuous variables or fourths of the variable distributions. The adjusted relative risk land 95% CI) for ischemic stroke in those in the highest versus lowest fourth were: von Willebrand factor, 1.71 (1.1 to 2.7); factor VIIIc, 1.93 (1.2 to 3.1); white blood cell count, 1.50 (0.9 to 2.4), fibrinogen. 1.26 (0.8 to 2.0); and protein C, 0.65 (0.4 to 1.0),Conclusions-This study offers modest support for the hypothesis that some markers of hemostatic function and inflammation can identify groups of middle-aged adults at increased risk of stroke. These factors may play a role in the pathogenesis of ischemic stroke.