Pre-term delivery and long-term risk of heart failure in women: a national cohort and co-sibling study
Pre-term delivery and long-term risk of heart failure in women: a national cohort and co-sibling study
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DOI：
10.1093/eurheartj/ehab789
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发表时间：
2021-11-24
影响因子：
39.3
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
--
作者：
Crump, Casey;Sundquist, Jan;Sundquist, Kristina
Aims Women who deliver pre-term have higher future risks of hypertension and ischaemic heart disease, but long-term risks of heart failure (HF) are unknown. We examined these risks in a large national cohort. Methods and results All 2 201 284 women with a singleton delivery in Sweden during 1973-2015 were followed up for inpatient or outpatient HF diagnoses through 2015. Cox regression was used to compute hazard ratios (HRs) for HF associated with pregnancy duration, adjusting for other maternal factors. Co-sibling analyses assessed for confounding by shared familial (genetic and/or environmental) factors. In 48.2 million person-years of follow-up, 19 922 women were diagnosed with HF (median age: 60.7 years). Within 10 years after delivery, the adjusted HR was 2.96 [95% confidence interval (CI): 2.48-3.53] for HF associated with pre-term (gestational age:
