Conductive 3D Ti3C2Tx MXene-Matrigel hydrogels promote proliferation and neuronal differentiation of neural stem cells.
Conductive 3D Ti3C2Tx MXene-Matrigel hydrogels promote proliferation and neuronal differentiation of neural stem cells.
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DOI：
10.1016/j.colsurfb.2023.113652
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发表时间：
2023-11
期刊：
影响因子：
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通讯作者：
Hao Wei;Yajun Gu;Ao Li;Panpan Song;Dingding Liu;Feihu Sun;Xiaofeng Ma;Xiaoyun Qian
中科院分区：
文献类型：
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作者：
Hao Wei;Yajun Gu;Ao Li;Panpan Song;Dingding Liu;Feihu Sun;Xiaofeng Ma;Xiaoyun Qian
神经干细胞(NSCs)移植在中枢神经系统损伤修复领域具有巨大的潜力，但移植NSCs的分化效率有限往往影响其治疗效果。本文介绍了一种稳定的MXenes-Matrigel水凝胶三维(3D)导电性水凝胶。得益于水凝胶的三维微孔网络结构，导电水凝胶可以为神经干细胞的生长提供细胞外基质样的基质。此外，随着Ti3C2TxMXenes的加入，复合材料具有良好的导电性和生物相容性。结果表明，MXene-Matrigel水凝胶能有效促进神经干细胞的增殖和分化。这些发现为理解传导水凝胶对神经干细胞的调节作用提供了实验证据，并为神经组织工程提供了新的策略。
Neural stem cells (NSCs) transplantation has great potential in the field of central nervous system injury repair, but the limited differentiation efficiency of transplanted NSCs often affects the therapeutic effect. In this paper, we present a stable three-dimensional (3D) conductive hydrogel prepared by cross-linking MXenes to Matrigel hydrogel. Benefiting from 3D microporous network structure of hydrogel, the conductive hydrogel can provide an extracellular matrix-like substrate for NSCs growth. Moreover, with the addition of Ti3C2TxMXenes, the composite has excellent electrical conductivity and biocompatibility. It is demonstrated that MXene-Matrigel hydrogels can effectively promote the proliferation and differentiation of NSCs. These findings provide experimental evidence for understanding the regulatory role of conductive hydrogels on NSCs and provides new strategies for neural tissue engineering.