Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T.
Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau-PET/MRI at 3T.
复制标题
使用 3T 同步 tau-PET/MRI，海马亚场成像和分数各向异性显示阿尔茨海默病 tau 进展的平行变化。
DOI：
10.1002/dad2.12218
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Zeineh MM
中科院分区：
文献类型：
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作者：
Carlson ML;Toueg TN;Khalighi MM;Castillo J;Shen B;Azevedo EC;DiGiacomo P;Mouchawar N;Chau G;Zaharchuk G;James ML;Mormino EC;Zeineh MM
阿尔茨海默病（AD）是最常见的痴呆症形式，其主要特征是两种蛋白质tau和淀粉样蛋白的异常聚集。我们在AD患者体内同时评估了海马体亚区tau病理学和白质连通性的变化。24名受试者同时使用飞行时间18F - PI - 2620 tau正电子发射断层扫描/3 -特斯拉磁共振成像和自动分割进行扫描。我们观察到，相对于对照组，鼻内/鼻周区域的tau蛋白广泛升高，菊角1/丘下的tau蛋白中度升高，齿状回的tau蛋白没有升高。弥散张量成像显示，与对照组相比，阿尔茨海默病和轻度认知障碍患者海马旁回的分数各向异性较低，并与嗅内皮层和嗅周围皮层的早期tau积聚密切相关。这项研究证明了18F - PI2620在海马亚区结合的可量化模式的潜力，伴随着扩散和体积指标，是AD的有价值的标志物。
Alzheimer's disease (AD) is the most common form of dementia, characterized primarily by abnormal aggregation of two proteins, tau and amyloid beta. We assessed tau pathology and white matter connectivity changes in subfields of the hippocampus simultaneously in vivo in AD. Twenty‐four subjects were scanned using simultaneous time‐of‐flight 18F‐PI‐2620 tau positron emission tomography/3‐Tesla magnetic resonance imaging and automated segmentation. We observed extensive tau elevation in the entorhinal/perirhinal regions, intermediate tau elevation in cornu ammonis 1/subiculum, and an absence of tau elevation in the dentate gyrus, relative to controls. Diffusion tensor imaging showed parahippocampal gyral fractional anisotropy was lower in AD and mild cognitive impairment compared to controls and strongly correlated with early tau accumulation in the entorhinal and perirhinal cortices. This study demonstrates the potential for quantifiable patterns of 18F‐PI2620 binding in hippocampus subfields, accompanied by diffusion and volume metrics, to be valuable markers of AD.