Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study
Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study
复制标题
空腹甘油三酯和血糖指数更适合识别中国成年人群代谢不健康个体：一项全国性研究
DOI：
--
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Qiuhe Ji
中科院分区：
文献类型：
--
作者：
Xinwen Yu;Li Wang;Qiuhe Ji
目的/引言：代谢不健康可以由代谢综合征的组成部分来定义，代谢综合征与胰岛素抵抗密切相关。我们的目的是确定一个简单的指标来识别中国成年人群的代谢不健康。材料与方法：从2007年6月至2008年5月进行的中国糖尿病和代谢紊乱研究中，共筛选了30，291名个体。代谢不健康的定义是使用代谢综合征的组成部分，腰围除外。我们比较了胰岛素抵抗的三个替代指标：空腹甘油三酯和葡萄糖（TyG）的乘积，甘油三酯除以高密度脂蛋白胆固醇和胰岛素抵抗的代谢评分，以评估代谢状态。结果如下：所有指标均具有较高的敏感性和特异性的识别代谢不健康，特别是TyG指数的曲线下面积为0.863男性和0.867女性。参与者被分成亚组进行进一步分析。TyG指数也显示出很高的诊断价值，特别是对于年轻人和腰围正常的男性。三个指数的性别特异性截止值也被用来定义代谢不健康。TyG指数显示出最高的协议与j值为0.603和0.605的男性和女性之间的代谢综合征的组成部分和三个指数。结论：我们认为TyG指数仅在一份血液实验室检查报告中读取，更简单，更适合于识别中国成年人群中代谢不健康的个体以及心脏代谢疾病的高危人群。
Aims/Introduction: Metabolic unhealth can be defined by the components of metabolic syndrome, which is closely connected to insulin resistance. We aimed to determine a simple index to identify metabolic unhealth in the Chinese adult population. Materials and Methods: A total of 30,291 individuals were screened from the China National Diabetes and Metabolic Disorders Study carried out from June 2007 to May 2008. Metabolic unhealth was defined using components of metabolic syndrome, except waist circumference. We compared the three surrogate indices of insulin resistance: the product of fasting triglycerides and glucose (TyG), triglycerides divided by high-density lipoprotein cholesterol and the metabolic score for insulin resistance for the evaluation of metabolic status. Results: All indices had high sensitivity and specificity for the identification of metabolic unhealth, especially the TyG index with an area under the curve of 0.863 for men and 0.867 for women. Participants were divided into subgroups for further analysis. The TyG index also showed high diagnostic values, especially for younger individuals and men with normal waist circumference. Sex-specific cut-offs for three indices were also used to define metabolic unhealth. The TyG index showed the highest agreement with j values of 0.603 and 0.605 for men and women between the components of metabolic syndrome and three indices. Conclusions: We propose that the TyG index, just read in one blood laboratory test report, is simpler and more suitable for the identification of metabolically unhealthy individuals as well as who have high risk of cardiometabolic diseases of the Chinese adult population..