MORPHINE AND ENDORPHINS MODULATE DOPAMINE TURNOVER IN RAT MEDIAN-EMINENCE
MORPHINE AND ENDORPHINS MODULATE DOPAMINE TURNOVER IN RAT MEDIAN-EMINENCE
复制标题
DOI：
10.1073/pnas.76.6.3006
复制
发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
MILLER, RJ
中科院分区：
文献类型：
--
作者：
DEYO, SN;SWIFT, RM;MILLER, RJ
内源性和外源性阿片类药物的一些作用（例如，刺激催乳素释放）是通过与儿茶酚胺能系统的相互作用介导的。吗啡（1.67、5和15 mg/kg体重，i.p.）改变了多巴胺的周转。雄性Sprague-Dawley大鼠正中隆起、新纹状体和额叶皮层的甲基-对酪氨酸方法。新纹状体多巴胺周转率降低。在额叶皮层，所有剂量都能有效减少多巴胺的周转；在中隆起，最低剂量的吗啡没有改变多巴胺的周转。所有三种剂量都加速了新纹状体中的多巴胺周转。纳洛酮在所有剂量下都能有效地逆转吗啡在所有大脑区域的作用，但单独给药时对脑循环没有影响。在胸正中、新纹状体和额叶皮层脑室内注射[D-Ala2，D-Leu5]-脑啡肽（25 .mu）。G)或。beta。-内啡肽（15 .mu）G)产生与吗啡相同的多巴胺转换效果。肽的作用被纳洛酮阻断。显然，阿片类药物和阿片肽通过降低结节基底多巴胺能系统的活性来增加催乳素的释放。
Some actions of endogenous and exogenous opioids (e.g., stimulation of prolactin release) are mediated by interaction with catecholaminergic systems. Morphine (1.67, 5 and 15 mg/kg of body wt, i.p.) altered dopamine turnover as measured by the .alpha.-methyl-p-tyrosine method in the median eminence, neostriatum and frontal cortex of male Sprague-Dawley rats. The turnover rate of dopamine was reduced in the neostriatum. In the frontal cortex all doses were effective in decreasing dopamine turnover; in the median eminence the lowest dose of morphine did not alter dopamine turnover. All 3 doses accelerated dopamine turnover in the neostriatum. Naloxone effectively reversed the effects of morphine at all doses in all brain areas, but did not effect turnover when given alone. In the median eminecne, neostriatum and frontal cortex intraventricular injection of [D-Ala2,D-Leu5]-enkephalin (25 .mu.g) or .beta.-endorphin (15 .mu.g) produced the same effects on dopamine turnover as morphine. The actions of peptides were blocked by naloxone. Apparently opiates and opioid peptides increase prolactin release by reducing the activity of the tuberoinfundibular dopaminergic system.