Dietary supplementation withN-carbamylglycinate (CGly) improved feed source proline absorption and reproductive performance in sows
Dietary supplementation withN-carbamylglycinate (CGly) improved feed source proline absorption and reproductive performance in sows
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日粮添加 N-氨甲酰甘氨酸 (CGly) 可改善母猪饲料源脯氨酸的吸收和繁殖性能
DOI：
10.1039/c9fo01940e
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发表时间：
2020
期刊：
影响因子：
6.1
通讯作者：
Shu XuGang
中科院分区：
文献类型：
--
作者：
Wan Dan;Li YiKun;Li GuanYa;Wu Xin;Zhang DongMing;Shu XuGang
在妊娠后期，由于胎儿胎盘单位和母体红细胞质量的快速增长，营养需求增加。甘氨酸、脯氨酸和精氨酸是促进胎儿生长发育的重要氨基酸。本研究旨在探讨甘氨酸衍生物（N-氨基甲酰甘氨酸，CGly）对妊娠后期母猪氨基酸组成和繁殖性能的影响。选择32头经产妊娠母猪（80 d），从妊娠第85天至分娩，随机分为两组：（1）对照组和（2）治疗组（CGly，800 mg kg-1）。研究了妊娠110天的血清氨基酸谱和繁殖性能。结果表明，妊娠后期日粮中添加CGly可显著提高围产期母猪血清中甘氨酸（p < 0.05）和脯氨酸（p < 0.01）的含量，并能显著提高围产期母猪的窝重（p < 0.05）和活产数（p < 0.1）。基于体外研究，脯氨酸水平的改善可能是由于SLC 6A 20和SLC 38 A2的诱导表达。进一步的研究应关注氨基酸吸收的细节，特别是不同氨基酸及其衍生物的竞争和合作吸收过程。
Nutrient requirements are increased in the late-gestation period due to the faster growth of the foetal-placental unit and maternal erythrocyte mass. Glycine, proline and arginine are important amino acids that could improve foetal growth and development. The present study aims to investigate the effects of a derivative of glycine (N-carbamylglycinate, CGly) on the amino acid profiles and reproductive performances of late gestation sows. Thirty-two multiparous gestating sows (∼d 80) were selected, and randomly assigned into two groups: (1) control and (2) treatment (CGly, 800 mg kg−1) from day 85 of gestation to parturition. The serum amino acid profiles at day 110 of gestation and reproductive performance were investigated. The results showed that dietary supplementation of CGly in the late gestation period significantly improved the levels of glycine (p < 0.05) and proline (p < 0.01) in the serum of the perinatal sows, and thereafter improved the litter birth weights (p < 0.05) and number born alive (p < 0.1). Based on the in vitro studies, the improvement of proline levels is probably due to the induced expression of SLC6A20 and SLC38A2. Further studies should focus on the details of amino acid absorption, especially the competitive and cooperative absorption processes for different amino acids and derivatives.