Reactive oxygen species in cancer stem cells of head and neck squamous cancer
Reactive oxygen species in cancer stem cells of head and neck squamous cancer
复制标题
头颈鳞状细胞癌干细胞中的活性氧。
DOI：
10.1016/j.semcancer.2018.06.001
复制
发表时间：
2018
影响因子：
14.5
通讯作者：
Andreas E Albers
中科院分区：
文献类型：
--
作者：
Xu Qian;Xiaobo Nie;Wenhao Yao;Konrad Klinghammer;Holger Sudhoff;Andreas M Kaufmann;Andreas E Albers
头颈部鳞状细胞癌(HNSCC)全身治疗的最大挑战之一是肿瘤细胞数量较少，即肿瘤干细胞(CSC)。CSC可以通过自身的自我更新能力再生和维持异种肿瘤。他们在化疗和放射治疗后更具抵抗力和存活率的潜在能力也得到了确认。进一步的研究表明，活性氧物种(ROS)参与了CSC相关的抗性。在这篇综述中，我们重点介绍了目前对HNSCC-CSC的认识，认为ROS是一种可能的、针对CSC的新的治疗方法。
One of the greatest challenges in systemic treatment of head and neck squamous cell carcinoma (HNSCC) is a small tumor cell population, namely, cancer stem-like cells (CSC). CSC can regenerate and maintain a heterogenic tumor by their self-renewal capacity. Their potential ability to be more resistant to and survival after chemo- and radiation therapy was also identified. Further studies have shown that reactive oxygen species (ROS) contribute to this CSC-associated resistance. In this review, we focus on the current knowledge of HNSCC-CSC, with regard to ROS as a possible and novel therapeutic approach in targeting CSC.