Measurement of local cerebral glucose utilization and its relation to local functional activity in the brain.
Measurement of local cerebral glucose utilization and its relation to local functional activity in the brain.
复制标题
局部脑葡萄糖利用率的测量及其与大脑局部功能活动的关系。
DOI：
10.1007/978-1-4684-5931-9_4
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发表时间：
1991
影响因子：
--
通讯作者：
L. Sokoloff
中科院分区：
文献类型：
--
作者：
L. Sokoloff
正常人类男性的大脑平均约占体重的2%，但消耗了全身基础耗氧量的20% （Sokoloff, 1989）。这种高能量代谢速率的底物通常几乎完全是葡萄糖（表1）（Sokoloff, 1960）。事实上，消耗的葡萄糖比氧气消耗完全氧化为二氧化碳和水的葡萄糖要多，这表明糖酵解的速率超过了糖酵解产物的氧化速率，通常约为20%（表1）。葡萄糖的糖酵解利用产生的多余碳可能分布在许多糖酵解和三羧酸循环途径的乳酸、丙酮酸和其他中间体中，这些中间体的数量微不足道，无法在脑血中检测到，也可能分布在几个神经递质池中，如乙酰胆碱、谷氨酸、GABA等。
The average normal, human male brain represents approximately 2% of total body weight but consumes about 20% of the total body basal oxygen consumption (Sokoloff, 1989). The substrate for this high rate of energy metabolism is normally almost exclusively glucose (TABLE 1) (Sokoloff, 1960). In fact, more glucose is consumed than can be oxidized completely to carbon dioxide and water by the oxygen consumption, indicating that the glycolytic rate exceeds the rate of oxidation of the products of glycolysis, normally by about 20% (Table 1). The excess carbon derived from glycolytic utilization of glucose is probably distributed in many, e.g., lactate, pyruvate, and other intermediates of the glycolytic and tricarboxylic acid cycle pathways that leave the brain in amounts too insignificant to be detected in the cerebral blood, and also into several neurotransmitter pools, such as acetylcholine, glutamate, GABA, etc.