TEAR EVAPORIMETER FOR MEASURING WATER EVAPORATION RATE FROM THE TEAR FILM UNDER CONTROLLED CONDITIONS IN HUMANS
TEAR EVAPORIMETER FOR MEASURING WATER EVAPORATION RATE FROM THE TEAR FILM UNDER CONTROLLED CONDITIONS IN HUMANS
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DOI：
10.1016/0014-4835(83)90086-6
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发表时间：
1983-01-01
影响因子：
3.4
通讯作者：
REFOJO, MF
中科院分区：
文献类型：
--
作者：
ROLANDO, M;REFOJO, MF
水从泪膜蒸发的速率取决于测定时的条件。如果在受控且易于重复的环境中进行测量，泪液蒸发率可以作为有用的诊断和研究工具。开发了一种泪液蒸发计，它提供了一种无创方法来评估具有正常或病理性泪膜的眼睛中的水分蒸发率。受试者[人类]配备一副经过改造的游泳护目镜，以便将测试眼睛上方的空气调节到所需的相对湿度基线（29.5%）和温度基线（23±1℃）。为了消除其他水源，护目镜下的眼睑和皮肤都涂有凡士林。要求受试者在 1 分钟测试期间保持睁开眼睛并避免眨眼。然后确定由于眼泪中的水分蒸发而导致的相对湿度的增加。眼睛暴露于蒸发的表面积是根据眼睑孔径计算的。测量 52 只正常眼睛的水分蒸发率（平均值 = 4.07 × 10-7 .+-. 0.40 × 10-7 g/cm2/s），并将结果与 52 只患有各种泪膜异常的眼睛获得的值进行比较（平均值 = 8.17 .+-. 10-7 .+-. 2.65 .+-. 10-7克/平方厘米每秒）。 2组间差异有统计学意义（P<0.01）。在正常眼中，滴入1滴0.5%丙美卡因后，蒸发率的增加有统计学意义。
The rate of water evaporation from the tear film depends on the conditions under which it is determined. If measured in a controlled and easily reproducible setting, tear evaporation rate could serve as a useful diagnostic and research tool. A tear evaporimeter was developed that provides a noninvasive method for evaluating water evaporation rate in eyes with normal or pathologic tear films. The subject [human] is fitted with a pair of swimmer''s goggles modified so that the air over the test eye is conditioned to a desired baseline of relative humidity (29.5%) and temperature (23 .+-. 1.degree. C). To eliminate other sources of water, the lids and skin under the goggles are covered with petroleum jelly. The subject is asked to keep his/her eye open and to avoid blinking during the 1-min test. The increase in relative humidity due to water evaporation from the tears is then determined. The surface area of the eye exposed to evaporation is calculated from the lid aperture. The water evaporation rate was measured in 52 normal eyes (average = 4.07 .times. 10-7 .+-. 0.40 .times. 10-7 g/cm2 per s) and compared the results with values obtained in 52 eyes with various tear-film abnormalities (average = 8.17 .+-. 10-7 .+-. 2.65 .+-. 10-7 g/cm2 per s). The difference between the 2 groups is statistically significant (P < 0.01). In normal eyes, after the instillation of 1 drop of 0.5% proparacaine, the increase in evaporation rate was statistically significant.