Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy

Effect of Smoking on Orbital Fat and Muscle Volume in Graves' Orbitopathy
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DOI：
10.1089/thy.2010.0218
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发表时间：
2011-02-01
期刊：
THYROID
影响因子：
6.6
通讯作者：
Mourits, Maarten P.
Mourits, Maarten P.
中科院分区：
医学1区
文献类型：
--
作者：
Regensburg, Noortje I.;Wiersinga, Wilmar M.;Mourits, Maarten P.

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背景：吸烟会对格雷夫斯眼眶病 (GO) 的病程和严重程度产生不利影响。香烟烟雾增强培养的人眼眶成纤维细胞的脂肪生成。本研究验证了我们的假设，即吸烟与 GO 患者眼眶脂肪增加有关。方法：这是一项观察性病例系列研究。在连续 95 名未经治疗的 GO 患者中，使用经过验证的软件计算了脂肪体积/眼眶体积 (FV/OV) 和肌肉体积/OV (MV/OV) 的比率。选择每位患者受影响最严重的眼眶进行分析。根据吸烟行为将患者分为两组。一组是当前吸烟者 (Sm+)，另一组是从不吸烟或至少 1 年不吸烟的人 (Sm-)。患者按 FV/OV 和 MV/OV 的三分位数分组，并在 Sm+ 和 Sm- 组之间进行 OV 对比。采用Jonckheere-Terpstra趋势分析和Mann-Whitney U检验分析GO的主要特征。结果：根据FV/OV分为三分位，GO患者中当前吸烟者的比例没有差异。相反，MV/OV 三分位数分析显示，MV 较大的患者中当前吸烟者的患病率较高。吸烟不影响 FV，但 Sm+ 组的 MV 明显大于 Sm- 组。 结论：吸烟与未经治疗的 GO 患者眼外 MV 增加有关，但与 FV 增加无关。
Background: Smoking adversely affects the course and severity of Graves' orbitopathy (GO). Cigarette smoke enhances adipogenesis in cultured human orbital fibroblasts. The present study tested our hypothesis that smoking is associated with increased orbital fat in GO patients.Methods: This was an observational case series study. In 95 consecutive patients with untreated GO, the ratios of fat volume/orbital volume (FV/OV) and muscle volume/OV (MV/OV) were calculated with validated software. The most affected orbit of each patient was chosen for analysis. Patients were divided into two groups based on smoking behavior. One group was current smokers (Sm+) and the other were those who never smoked or those who had not smoked for at least 1 year (Sm-). Patients were grouped in tertiles of FV/OV and MV/OV and contrast in OVs between the Sm+ and Sm- group. The main characteristics of GO were analyzed using Jonckheere-Terpstra trend analysis and Mann-Whitney U-test.Results: The proportion of current smokers was not different in GO patients when divided in tertiles according to their FV/OV. In contrast, analysis of MV/OV tertiles showed a trend to a higher prevalence of current smokers in patients with larger MVs. Smoking did not influence FV, but the Sm+ group had significantly larger MVs than the Sm- group.Conclusion: Smoking is associated with an increase in extraocular MV in untreated patients with GO and not with an increase in FV.