Design and properties of graded polyamide12/hydroxyapatite scaffolds based on primitive lattices using selective laser sintering
Design and properties of graded polyamide12/hydroxyapatite scaffolds based on primitive lattices using selective laser sintering
复制标题
使用选择性激光烧结基于原始晶格的分级聚酰胺12/羟基磷灰石支架的设计和性能
DOI：
10.1016/j.jmbbm.2021.105052
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
于天麟
中科院分区：
文献类型：
--
作者：
赵泽;李军超;韦苑;于天麟
Scaffolds with favorable biological characteristics and controlled functional gradient architectures are preferable for the repair of damaged tissues in bone tissue engineering. In this study, the triply periodic minimal surfaces (TPMS) were introduced to design functional gradient porous scaffolds based on Primitive lattices which were then manufactured by selective laser sintering (SLS) using pure polyamide12 (PA12) material and PA12/hydroxyapatite (HA) composite material. The mechanical properties and permeability of the scaffolds were then evaluated by mechanical compression experiments and computational fluid dynamics (CFD) analysis. The radial-graded scaffold was found to have superior good mechanical properties and permeability and be favorable for the subsequent growth of bone tissue. Further, the optimal PA12/HA composition was determined by analyzing the effect of the addition of HA particles on the hydrophilicity and mechanical properties of the composite scaffold. Additionally, the cytotoxicity tests were performed to evaluate the effects of PA12/HA gradient scaffold on cell growth. The obtained results demonstrate that the radial gradient scaffold with 15% HA addition exhibits a feasible combination of comprehensive performance and biological activity, indicating a great application potential in the field of bone tissue engineering.
