Tumor diagnosis preceding Parkinson's disease: A case-control study
Tumor diagnosis preceding Parkinson's disease: A case-control study
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DOI：
10.1002/mds.20123
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发表时间：
2004-07-01
影响因子：
8.6
通讯作者：
Savettieri, G
中科院分区：
文献类型：
--
作者：
D'Amelio, M;Ragonese, P;Savettieri, G
据报道，与普通人群相比，帕金森病（PD）患者的癌症风险较低。然而，大多数研究都是基于死亡证明。我们设计了一个病例对照研究，以评估PD发作前肿瘤与PD的关系。PD患者按年龄和性别与PD患者相匹配，PD患者从病例居住地的市政府中随机选择。通过结构化问卷评估PD发作前肿瘤的发生率。肿瘤分为良性、恶性或分类不确定，与内分泌相关或无关。使用条件逻辑回归计算比值比（OR），并根据肿瘤类别和风险因素进行调整。我们纳入了222例PD患者。癌症的发生率为6.8%，对照组为12.6%。PD患者的肿瘤风险降低（校正OR，0.4; 95%置信区间[CI]，0.2-0.7）。仅女性的风险降低（调整后的OR，0.3; 95%CI，0.1-0.7）。PD患者发生恶性肿瘤（校正OR，0.6; 95% CI，0.1-2.5）和非恶性肿瘤（校正OR，0.3; 95% CI，0.1-0.7）的风险均降低。尽管如此，内分泌相关肿瘤（校正OR，0.3; 95%CI，0.1-0.9）和非内分泌相关肿瘤（校正OR，0.4; 95%CI，0.1-0.9）的风险仍有所降低。我们的研究证实了以前流行病学研究中报道的PD和肿瘤之间的负相关。(C)2004年，《运动障碍协会》。
Lower cancer risk in Parkinson's disease (PD) patients compared to the general population has been reported. However, most of the studies were based on death certificates. We designed a case-control study to estimate the association of tumor preceding PD onset and PD. PD patients were matched by age and gender to PD-free individuals, randomly selected from the municipalities of residence of cases. Occurrence of tumors preceding PD onset was assessed through a structured questionnaire. Neoplasms were categorized as benign, malignant, or of uncertain classification, and endocrine-related or not. Odds ratios (OR) were calculated using conditional logistic regression and adjusted for tumor categories and risk factors. We included 222 PD patients. Frequency of cancer was 6.8% for cases, 12.6% for controls. PD patients had a decreased risk for neoplasms (adjusted OR, 0.4; 95% confidence interval [CI], 0.2-0.7). Risk was reduced only for women (adjusted OR, 0.3; 95% Cl, 0.1-0.7). PD patients had a decreased risk both for malignant (adjusted OR, 0.6; 95% Cl, 0.1-2.5) and nonmalignant neoplasms (adjusted OR, 0.3; 95% CI, 0.1-0.7). Still, risk was decreased for endocrine-related tumors (adjusted OR, 0.3; 95% CI, 0.1-0.9) and non-endocrine-related tumors (adjusted OR, 0.4; 95% Cl, 0.1-0.9). Our study confirms the inverse association between PD and neoplasms reported in previous epidemiologic studies. (C) 2004 Movement Disorder Society.