EXTRAPITUITARY ACTION OF GONADOTROPIN-RELEASING HORMONE - DIRECT INHIBITION OF OVARIAN STEROIDOGENESIS
EXTRAPITUITARY ACTION OF GONADOTROPIN-RELEASING HORMONE - DIRECT INHIBITION OF OVARIAN STEROIDOGENESIS
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DOI：
10.1126/science.375393
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发表时间：
1979-01-01
期刊：
影响因子：
56.9
通讯作者：
ERICKSON, GF
中科院分区：
文献类型：
--
作者：
HSUEH, AJW;ERICKSON, GF
促性腺激素释放激素（GnRH）及其激动剂类似物抑制卵泡刺激素（FSH）诱导的大鼠卵巢颗粒细胞雌激素和孕激素分泌的增加。同样地，GnRH类似物在体内抑制垂体切除大鼠中FSH诱导的卵巢功能变化。GnRH除了在垂体中释放促性腺激素外，还直接抑制卵巢类固醇的生成。
Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function is hypophysectomized rats in vivo. GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.