Adaptive and Injury Response of Bone to Mechanical Loading.
Adaptive and Injury Response of Bone to Mechanical Loading.
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DOI：
10.1038/bonekey.2012.192
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发表时间：
2012-10
期刊：
影响因子：
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通讯作者：
Sarah H. McBride;Matthew J. Silva
中科院分区：
文献类型：
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作者：
Sarah H. McBride;Matthew J. Silva
骨通过增加骨形成对超生理机械负荷作出反应。根据施加的应变大小（和其他载荷参数），响应可以是自适应的（主要是板层骨）或损伤（主要是编织骨）。Hert、Lanyon和Rubin最初的研究建立了骨机械敏感性的基本“规则”。随后的研究使用非侵入性啮齿类动物负荷模型，最值得注意的是特纳等人。最近的工作与这些模型已经能够探索结构，转录和分子机制，区分两种反应（层状与编织）。Wnt/Lrp信号转导已成为板层骨的关键机械反应途径。然而，关于衰老、骨细胞、其他信号通路以及调节板层骨与编织骨形成的分子调控的影响，仍有许多研究要做。这篇综述不仅总结了历史发现，而且还总结了这些主题的当前数据。
Bone responds to supraphysiological mechanical loads by increasing bone formation. Depending on the applied strain magnitude (and other loading parameters) the response can be either adaptive (mostly lamellar bone) or injury (mostly woven bone). Seminal studies of Hert, Lanyon and Rubin originally established the basic 'rules' of bone mechanosensitivity. These were reinforced by subsequent studies using noninvasive rodent loading models, most notably by Turner et al. More recent works with these models have been able to explore the structural, transcriptional and molecular mechanisms which distinguish the two responses (lamellar vs woven). Wnt/Lrp signaling has emerged as a key mechanoresponsive pathway for lamellar bone. However, there is still much to study with regard to effects of ageing, osteocytes, other signaling pathways, and the molecular regulation that modulates lamellar vs woven bone formation. This review summarizes not only the historical findings but also the current data for these topics.