EFFECTS OF PARA-AMINOBENZOIC ACID, INSULIN, AND GENTAMICIN ON PLASMODIUM-FALCIPARUM DEVELOPMENT IN ANOPHELINE MOSQUITOS (DIPTERA, CULICIDAE)
EFFECTS OF PARA-AMINOBENZOIC ACID, INSULIN, AND GENTAMICIN ON PLASMODIUM-FALCIPARUM DEVELOPMENT IN ANOPHELINE MOSQUITOS (DIPTERA, CULICIDAE)
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DOI：
10.1093/jmedent/31.4.561
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发表时间：
1994-07-01
影响因子：
2.1
通讯作者：
DAVIS, JR
中科院分区：
文献类型：
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作者：
BEIER, MS;PUMPUNI, CB;DAVIS, JR
冈比亚按蚊Giles sensu lato（s.l.）和一个. stephensi Liston作为成虫暴露于对氨基苯甲酸（PABA）、人胰岛素或硫酸庆大霉素（一种抗微生物溶液），以确定它们对恶性疟原虫Welch发育至卵囊阶段的影响。对于这两种蚊子，浓度为0.001至0.05%的PABA没有影响卵囊感染率或卵囊密度。在较高浓度下，PABA喂养的蚊子在实验感染后暴露时，卵囊感染率降低，但在实验感染前则没有。胰岛素喂养的蚊子有显着较高的卵囊感染率比对照组和增加的卵囊密度在两个安。gambiae s.1和An.史蒂芬西对寄生虫发育的最显著影响是观察到以庆大霉素喂养的蚊子。为了安。冈比亚公司喂食0.05%庆大霉素后，卵囊感染率是对照组的3.7倍，而卵囊密度是对照组的5.7倍。以0.1%庆大霉素饲料喂养的斯氏按蚊感染率高2.4倍，卵囊密度增加。浓度高于0.1%的庆大霉素对蚊子的生存和消化血餐的能力有有害影响。这些发现提供了有关抗生素、激素和代谢物如何影响恶性疟原虫在An中的发育的见解。冈比亚公司和一个.史蒂芬西
Anopheles gambiae Giles sensu lato (s.l.) and An. stephensi Liston were exposed as adults to para-aminobenzoic acid (PABA), human insulin, or gentamicin sulfate, an antimicrobial solution, to determine their effects on Plasmodium falciparum Welch development to the oocyst stage. For both mosquito species, concentrations of PABA from 0.001 to 0.05% had no effect on either oocyst infection rates or oocyst densities. At higher concentrations, PABA-fed mosquitoes had decreased oocyst infection rates when they were exposed after, but not before, experimental infections. Insulin-fed mosquitoes had significantly higher oocyst infection rates than controls and increased oocyst densities in both An. gambiae s.1 and An. stephensi. The most dramatic impact on parasite development was observed for mosquitoes fed on gentamicin. For An. gambiae s.l. fed 0.05% gentamicin, oocyst infection rates were 3.7-fold higher than in controls, whereas oocyst densities were 5.7 times greater than in controls. Anopheles stephensi fed on diets of 0.1% gentamicin had 2.4-fold higher infection rates and increased oocyst densities. Concentrations of gentamicin above 0.1% had deleterious effects on mosquito survival and their ability to digest blood meals. These findings provide insight into how antibiotics, hormones, and metabolites may affect the development of P. falciparum in An. gambiae s.l. and An. stephensi.