Fix it, don't trash it: Ribosome maintenance by chaperone-mediated repair of damaged subunits.

Fix it, don't trash it: Ribosome maintenance by chaperone-mediated repair of damaged subunits.
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修复它,不要丢弃它:通过伴侣介导的受损亚基修复来维持核糖体。

DOI:
10.1016/j.molcel.2023.04.006
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发表时间:
2023
期刊:
影响因子:
16
通讯作者:
Brar,GloriaAnn
Brar,GloriaAnn
中科院分区:
生物学1区
文献类型:
--
作者:
Spiri,Silvan;Brar,GloriaAnn

文献摘要

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急性应激源或正常的细胞功能可能导致核糖体蛋白损伤,从而威胁到功能核糖体库和翻译。在本期中,Yang等人展示了伴侣可以提取受损的核糖体蛋白,并用新合成的版本来取代它们,以修复成熟的核糖体。
Acute stressors or normal cellular function may result in ribosomal protein damage, which threatens the functional ribosome pool and translation. In this issue, Yang et al.1show that chaperones can extract damaged ribosomal proteins and replace them with newly synthesized versions to repair mature ribosomes.