Lipid Metabolic Regulatory Crosstalk Between Cancer Cells and Tumor-Associated Macrophages.
Lipid Metabolic Regulatory Crosstalk Between Cancer Cells and Tumor-Associated Macrophages.
复制标题
肿瘤细胞和肿瘤相关巨噬细胞之间的脂代谢调节串扰。
DOI：
10.1089/dna.2023.0071
复制
发表时间：
2023-08
影响因子：
3.1
通讯作者：
Shu Liu;Yingying Shen;Liyang Yin;Jianghua Liu;Xuyu Zu
中科院分区：
文献类型：
--
作者：
Shu Liu;Yingying Shen;Liyang Yin;Jianghua Liu;Xuyu Zu
在肿瘤微环境中，肿瘤相关巨噬细胞（tumor-associated macrophages，TAMs）是最丰富的细胞群之一，在肿瘤发生、化疗耐药性、免疫逃避和转移中起关键作用。TAM与癌细胞之间存在重要的相互作用：一方面，肿瘤控制浸润巨噬细胞的功能，有助于TAM的重编程，另一方面，TAM影响癌细胞的生长。本文综述了肿瘤细胞与TAMs之间复杂关系中的脂质代谢变化。我们讨论了癌细胞中的脂质代谢如何影响巨噬细胞的表型和代谢变化，以及随后TAMs的脂质代谢改变如何影响肿瘤进展。确定影响肿瘤细胞和TAM之间复杂相互作用的代谢变化也是探索新的治疗方法的重要一步，这些方法靶向免疫细胞的代谢重编程，以增强其杀肿瘤潜力和旁路治疗抗性。我们的工作可能为抗肿瘤治疗提供新的靶点。
In the tumor microenvironment, tumor-associated macrophages (TAMs) are one of the most abundant cell populations, playing key roles in tumorigenesis, chemoresistance, immune evasion, and metastasis. There is an important interaction between TAMs and cancer cells: on the one hand, tumors control the function of infiltrating macrophages, contributing to reprogramming of TAMs, and on the other hand, TAMs affect the growth of cancer cells. This review focuses on lipid metabolism changes in the complex relationship between cancer cells and TAMs. We discuss how lipid metabolism in cancer cells affects macrophage phenotypic and metabolic changes and, subsequently, how altered lipid metabolism of TAMs influences tumor progression. Identifying the metabolic changes that influence the complex interaction between tumor cells and TAMs is also an important step in exploring new therapeutic approaches that target metabolic reprogramming of immune cells to enhance their tumoricidal potential and bypass therapy resistance. Our work may provide new targets for antitumor therapies.