Smoking, Smoking Cessation, and Risk of Mortality in a Japanese Working Population - Japan Epidemiology Collaboration on Occupational Health Study -
Smoking, Smoking Cessation, and Risk of Mortality in a Japanese Working Population - Japan Epidemiology Collaboration on Occupational Health Study -
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DOI：
10.1253/circj.cj-18-0404
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发表时间：
2018-12-01
影响因子：
3.3
通讯作者：
Dohi, Seitaro
中科院分区：
文献类型：
--
作者：
Akter, Shamima;Nakagawa, Tohru;Dohi, Seitaro
背景：吸烟对工作年龄成年人死亡率的影响尚不清楚。因此，我们比较了吸烟和戒烟对日本工作人群总死亡率和原因特异性死亡率的影响。方法与结果：本研究包括参加日本职业健康流行病学合作研究的79114名年龄在20-85岁之间的日本工人。死亡和死因是根据死亡证明、病假文件、家属确认书和其他来源确定的。通过Cox比例风险回归估计风险比（hr）和95%置信区间（CIs）。在长达6年的随访期间，总共有252人死亡。在当前吸烟者和从不吸烟者中，总死亡率、心血管疾病死亡率和烟草相关癌症死亡率的多变量调整hr （95% ci）分别为1.49（1.10-2.01）、1.79（0.99-3.24）和1.80（1.02-3.19）。在当前吸烟者中，总死亡率、烟草相关癌症和心血管疾病死亡率的风险随着卷烟消费量的增加而增加（p趋势=基线前5年），总死亡率的hr （95% ci）分别为1.80（1.00-3.25）和1.02（0.57-1.82）。结论：在这组工人中，吸烟与所有和特定原因（包括心血管疾病和烟草相关癌症）导致的死亡风险增加有关，尽管这些风险在戒烟5年后有所降低。
Background: The effect of smoking on mortality in working-age adults remains unclear. Accordingly, we compared the effects of cigarette smoking and smoking cessation on total and cause-specific mortality in a Japanese working population.Methods and Results: This study included 79,114 Japanese workers aged 20-85 years who participated in the Japan Epidemiology Collaboration on Occupational Health Study. Deaths and causes of death were identified from death certificates, sick leave documents, family confirmation, and other sources. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated via Cox proportional hazards regression. During a maximum 6-year follow-up, there were 252 deaths in total. Multivariable-adjusted HRs (95% CIs) for total mortality, cardiovascular disease (CVD) mortality, and tobacco-related cancer mortality were 1.49 (1.10-2.01), 1.79 (0.99-3.24), and 1.80 (1.02-3.19), respectively, in current vs. never smokers. Among current smokers, the risks of total, tobacco-related cancer, and CVD mortality increased with increasing cigarette consumption (P-trend= 5 years before baseline had HRs (95% CIs) for total mortality of 1.80 (1.00-3.25) and 1.02 (0.57-1.82), respectively.Conclusions: In this cohort of workers, cigarette smoking was associated with increased risk of death from all and specific causes (including CVD and tobacco-related cancer), although these risks diminished 5 years after smoking cessation.