Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients
Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients
复制标题
DOI：
10.1007/s10067-010-1474-7
复制
发表时间：
2010-12-01
影响因子：
3.4
通讯作者：
Hollenberg, Morley D.
中科院分区：
文献类型：
--
作者：
Blanco, Ignacio;Beritze, Nana;Hollenberg, Morley D.
福尔马林固定，石蜡包埋的皮肤组织切片收集自匹配队列的63名纤维肌痛综合征（FMS）患者和49名志愿者从一般人群与α 1-抗胰蛋白酶（AAT）正常和缺陷的变种。检查这些组织中广谱抑制剂AAT、丝氨酸蛋白酶弹性蛋白酶和类胰蛋白酶、促炎细胞因子MCP-1和TNF α、内皮生物标志物VEGF和炎症/伤害感受相关受体PAR的表达（2）。这项研究最相关的发现是所有FMS患者乳头状真皮中肥大细胞（MC）的数量显著增加（每个显微镜高倍视野大于或等于5至14个），而对照组为0至1个（p
Formalin-fixed, paraffin-embedded skin tissue sections were collected from a matched cohort of 63 fibromyalgia syndrome (FMS) patients and 49 volunteers from the general population with both alpha1-antitrypsin (AAT) normal and deficiency variants. These tissues were examined for the expression of the broad-spectrum inhibitor AAT, the serine proteinases elastase and tryptase, the proinflammatory cytokines MCP-1 and TNF alpha, the endothelium biomarker VEGF, and the inflammation/nociception-related receptor PAR(2). The most relevant finding of the study was a significantly increased number of mast cells (MCs) in the papillary dermis of all FMS patients (greater than or equal to five to 14 per microscopic high power field) compared to zero to one in controls (p