Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome.
Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome.
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结合珠蛋白多态性是阻塞性睡眠呼吸暂停综合征患者心血管疾病的危险因素。
DOI：
10.1093/sleep/26.5.592
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发表时间：
2003
期刊：
影响因子：
5.6
通讯作者：
Levy,AndrewP
中科院分区：
文献类型：
--
作者：
Lavie,Lena;Lotan,Rachel;Hochberg,Irit;Herer,Paula;Lavie,Peretz;Levy,AndrewP
研究目的阻塞性睡眠呼吸暂停综合征与心血管疾病的风险显著增加有关。氧化应激和白细胞粘附性的增加被认为是导致这些患者易感性增加的基本病理生理机制。结合珠蛋白是一种抗氧化剂和免疫调节蛋白，由两个具有完全不同生物物理和生化性质的等位基因编码。因此，我们试图确定结合珠蛋白表型是否是阻塞性睡眠呼吸暂停综合征患者心血管疾病的决定因素。设计通过凝胶电泳法测定了465名阻塞性睡眠呼吸暂停综合征患者和757名非阻塞性睡眠呼吸暂停综合征患者的结合珠蛋白表型。在以色列北部的海法设立八床技术睡眠医学中心。参与者由于睡眠和健康工业工人怀疑存在呼吸障碍而要求进行睡眠记录。测量和结果与阻塞性睡眠呼吸暂停综合征和心血管疾病患者相比，阻塞性睡眠呼吸暂停综合征患者和无心血管疾病的阻塞性睡眠呼吸暂停综合征患者的3种触珠蛋白表型分布有显著差异。在有和没有心血管疾病的对照组之间，没有发现结合珠蛋白表型频率的差异。对数线性分析显示，结合珠蛋白表型和睡眠呼吸暂停的存在对心血管疾病的存在有显著的交互作用。Logistic回归分析显示，55岁以下携带结合珠蛋白2-2的睡眠呼吸暂停患者发生心血管疾病的风险是携带结合珠蛋白2-1的患者的2.32倍。结论结合珠蛋白表型是决定阻塞性睡眠呼吸暂停综合征心血管疾病易感性的重要危险因素，其机制可能与结合珠蛋白2等位基因蛋白产物的抗氧化和抗炎作用降低有关。
Study ObjectivesObstructive sleep apnea syndrome is associated with a marked increase in the risk for cardiovascular disease. Increased oxidative stress and leukocyte adhesiveness have been implicated as fundamental pathophysiologic mechanisms underlying the increased susceptibility in these patients. Haptoglobin is an antioxidant and immunomodulatory protein encoded by 2 alleles with profoundly different biophysical and biochemical properties. We therefore sought to determine if the haptoglobin phenotype was a determinant of cardiovascular disease in patients with obstructive sleep apnea syndrome.DesignHaptoglobin phenotype was determined by gel electrophoresis in 465 patients with and 757 individuals without obstructive sleep apnea syndrome.SettingEight-bed Technion Sleep Medicine Center in Haifa, serving the northern part of Israel.ParticipantsPatients referred for sleep recordings because of suspected breathing disorders in sleep and healthy industry workers.Measurements and ResultsPatients with obstructive sleep apnea syndrome and cardiovascular disease had a significantly different distribution of the 3 haptoglobin phenotypes as compared to patients with obstructive sleep apnea syndrome but without cardiovascular disease. No difference in the haptoglobin phenotype frequency was found between controls with and without cardiovascular disease. Log linear analysis revealed a significant interaction effect of haptoglobin phenotype and the presence of sleep apnea on the presence of cardiovascular disease. Logistic regression analysis revealed that the risk of cardiovascular disease in sleep apnea patients younger than 55 years with haptoglobin 2-2 was 2.32-fold higher than in their counterparts with haptoglobin 2-1.ConclusionsThese results suggest that haptoglobin phenotype is an important risk factor in determining susceptibility to cardiovascular disease in obstructive sleep apnea syndrome, which may be mediated by the decreased antioxidant and antiinflammatory actions of the haptoglobin 2 allelic protein product.