Analysis of Migraine Pathophysiology by Magnetic Resonance Imaging
Analysis of Migraine Pathophysiology by Magnetic Resonance Imaging
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DOI：
10.21926/obm.neurobiol.2201115
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发表时间：
2021-10
期刊：
影响因子：
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通讯作者：
Yasushi Shibata;Masayuki Goto;Sumire Ishiyama
中科院分区：
文献类型：
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作者：
Yasushi Shibata;Masayuki Goto;Sumire Ishiyama
磁共振成像（MRI）已被用于研究偏头痛的病理生理学，因为它是一种非侵入性的技术。头痛患者临床影像学检查的主要目的是排除器质性病变引起的继发性头痛。常规结构成像技术如常规MRI显示偏头痛患者的白色病变、灰质体积或皮质厚度的变化以及脑血流。通过磁共振光谱法观察代谢物水平的变化。扩散张量成像、神经突方向弥散、密度成像和功能性MRI揭示了脑微结构的动态实时功能变化。这些分析不仅用于比较偏头痛患者和健康对照组，而且用于了解周期性偏头痛发作期脑功能的动态变化。虽然这些分析已经证明了偏头痛的病理生理学，但仍然有许多局限性。随着成像技术的进步，对这一课题的进一步研究正在进行中。
Magnetic resonance imaging (MRI) has been used to investigate migraine pathophysiology because it is a non-invasive technique. The main aim of clinical imaging for patients with headaches is to exclude secondary headaches due to organic lesions. Conventional structural imaging techniques such as routine MRI demonstrate white matter lesions, changes in gray matter volume or cortical thickness, and cerebral blood flow in patients with migraine. Changes in metabolite levels are observed by magnetic resonance spectroscopy. Diffusion tensor imaging, neurite orientation dispersion, density imaging, and functional MRI reveal dynamic real-time functional changes in brain microstructures. These analyses have been applied not only for comparing patients with migraine and healthy controls but also for understanding the dynamic changes in brain function during the cyclic migraine ictal phase. Although these analyses have demonstrated migraine pathophysiology, there are still many limitations. Following the improvement in imaging technology, further research on this topic is in progress.