Salivary IgA secretion rate in young and elderly persons
Salivary IgA secretion rate in young and elderly persons
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DOI：
10.1016/0031-9384(95)02161-2
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发表时间：
1996-07-01
影响因子：
2.9
通讯作者：
SattelyMiller, EA
中科院分区：
文献类型：
--
作者：
Miletic, ID;Schiffman, SS;SattelyMiller, EA
免疫球蛋白A（伊加）是所有粘膜表面上的主要免疫球蛋白同种型，在粘膜表面它充当抵抗微生物入侵的第一道防线。最近的研究表明，分泌型伊加（sIgA）浓度在一天中由于一系列变量而变化，包括饮食因素，日常情绪和运动。本研究用ELISA法测定了48例青年（20-30岁）和老年（60-80岁）人唾液伊加含量。在连续7天期间收集未刺激的、稳定的早晨和下午唾液。唾液流，总蛋白，sIgA浓度和sIgA分泌率进行了测定。主要发现是老年人的唾液流量和sIgA分泌率明显低于年轻人。唾液伊加分泌率被认为是独立的总蛋白分泌的所有样品。在特定年龄组中存在个体差异。还发现压力和日常事件影响sIgA分泌率。
Immunoglobulin A (IgA) is the dominant immunoglobulin isotype on all mucosal surfaces where it acts as a first line of defense against microbial invasion. Recent investigations suggest that secretory IgA (sIgA) concentrations vary over the day due to a range of variables including dietary factors, daily mood, and exercise. In this study, salivary IgA was determined by ELISA in samples of 48 persons grouped as ''young'' (20-30 years old) and ''elderly'' (60-80 years old). Unstimulated, stabilized morning and afternoon saliva was collected during 7 consecutive days. Saliva now, total proteins, sIgA concentrations, and sIgA secretion rates were determined. The main finding was that saliva flow and sIgA secretion rate were significantly lower in the elderly than in the young. Salivary IgA secretion rate was found to be independent of total proteins secreted in all samples. There is individual variability within a particular age group. It was also found that stress and daily events influence the sIgA secretion rate.